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Synthesis
DOI: 10.1055/a-2515-0227
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Cobalt-Catalyzed Regioselective Hydroformylation of Allylic Alcohol Esters

Zhenhao Du
1   State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry Chinese Academy of Sciences, Shanghai, China (Ringgold ID: RIN58309)
,
Wenxin Lu
2   Department of Chemistry, Yale University, New Haven, United States (Ringgold ID: RIN5755)
,
Qinglei Chong
1   State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry Chinese Academy of Sciences, Shanghai, China (Ringgold ID: RIN58309)
,
Fanke Meng
3   State Key Laboratory of Organic Chemistry, Shanghai Institute of Organic Chemistry Chinese Academy of Sciences, Shanghai, China (Ringgold ID: RIN58309)
› Author AffiliationsSupported by: National Key Research and Development Program of China 2022YFA1506100
Supported by: National Natural Science Foundation of China 22371294, 21821002
Supported by: the Strategic Priority Research Program of the Chinese Academy of Sciences XDB0610000
Supported by: Beijing National Laboratory for Molecular Sciences BNLMS202304
Supported by: Science and Technology Commission of Shanghai Municipality 20XD1425000
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Aliphatic aldehydes are important building blocks in organic synthesis due to their high reactivity and versatility. Here, we reported a simple, mild and efficient method for hydroformylation of allyl alcohol esters under cobalt catalysis. This research was distinguished by its good functional group tolerance, moderate to good yields and exclusive chemo- and regioselectivity, making this protocol an attractive way to prepare aldehyde products with linear selectivity.



Publication History

Received: 14 November 2024

Accepted after revision: 11 January 2025

Accepted Manuscript online:
11 January 2025

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