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Horm Metab Res 2025; 57(03): 149-155
DOI: 10.1055/a-2530-1792
Review

Normotensive Primary Aldosteronism – Does it Exist?

Huai Heng Loh 
1   Faculty of Medicine, University Malaysia of Sarawak, Kota Samarahan, Malaysia (Ringgold ID: RIN54706)
2   Faculty of Medicine, National University of Malaysia, Cheras, Malaysia (Ringgold ID: RIN458203)
,
Norlela Sukor 
2   Faculty of Medicine, National University of Malaysia, Cheras, Malaysia (Ringgold ID: RIN458203)
3   Faculty of Medicine, Hospital Canselor Tuanku Muhriz UKM, Cheras, Malaysia (Ringgold ID: RIN60607)
› Author AffiliationsSupported by: University of Malaysia Sarawak UNI/F05/PILOT/85091/2022
Supported by: National University of Malaysia FF-2022-066
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Abstract

Heightened aldosterone levels are associated with increased risk of renal sequelae, cardiovascular morbidity and mortality. Historically, primary aldosteronism is linked to hypertension. However, growing evidence reveals its presence even in normotensive individuals. This review consolidates data from diverse sources, delves into clinical studies of this underexplored condition, discusses the potential mechanisms, and provides a comprehensive and an up-to-date overview of the current state of knowledge. It highlights the evidence and understanding of normotensive primary aldosteronism, summarizes findings, and identifies opportunities for future research in this area. By addressing the clinical evidence, risk of hypertension development and possible mechanisms involved, this review aims to advance the understanding of this distinct form of primary aldosteronism and inspire further research in this emerging field.

Keywords

hyperaldosteronism - RAAS - normotension - aldosterone-producing cell cluster - subclinical hyperaldosteronism


Publication History

Received: 24 October 2024

Accepted after revision: 23 January 2025

Article published online:
06 March 2025

© 2025. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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