Download PDF
Synlett
DOI: 10.1055/a-2535-0823
letter

Cobalt-Catalyzed Reductive Heck Cyclization Using Water as Hydrogen Donor to Access Oxindoles

Li-Dong Sun
1   College of Chemistry and Chemical Engineering, Shantou University, Shantou, China (Ringgold ID: RIN12386)
,
Qian Xiao
2   School of Chemistry and Environmental Engineering, Hanshan Normal University, Chaozhou, China (Ringgold ID: RIN47883)
,
Sanliang Li
1   College of Chemistry and Chemical Engineering, Shantou University, Shantou, China (Ringgold ID: RIN12386)
,
Jian-Ji Zhong
3   Department of Chemistry, Shantou University, Shantou, China (Ringgold ID: RIN12386)
› Author AffiliationsSupported by: Characteristic Innovation Project of Guangdong Colleges and Universities 2024KTSCX108
Supported by: National Natural Science Foundation of China 22171177
Supported by: Guangdong-Hong Kong Joint Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province 2023B1212120011
Supported by: Guangdong Basic and Applied Basic Research Foundation 2023A1515110791
Supported by: 2022 Scientific Research Start-up Funds of Hanshan Normal University QD202208
› Further Information
  PDF Download All articles of this category

An efficient cobalt-catalyzed intramolecular reductive Heck reaction using water as hydrogen donor for the synthesis of valuable 3,3-disubstituted oxindoles from 2-halo-N-arylacrylamides was described herein. Such an approach features operational simplicity and high functional group tolerance. Importantly, when the reaction was performed in D2O, the deuterated oxindoles could be rapidly accessed in a facile and low-cost manner.



Publication History

Received: 12 January 2025

Accepted after revision: 07 February 2025

Accepted Manuscript online:
07 February 2025

© . Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany