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Z Geburtshilfe Neonatol
DOI: 10.1055/a-2542-2818
Original Article

The Correlation of Vitamin D Concentrations in Healthy Pregnant Women and Their Infants with Outcome Parameters

Marjana Jerković Raguž 
1   Department of Neonatology, Clinic for Children’s Diseases, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina (Ringgold ID: RIN290968)
2   School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina (Ringgold ID: RIN159223)
,
Tatjana Barišić
2   School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina (Ringgold ID: RIN159223)
3   Clinic of Gynecology and Obstetrics, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina (Ringgold ID: RIN290968)
,
Ivanka Mikulić
2   School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina (Ringgold ID: RIN159223)
4   Department of Laboratory Diagnostics, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina (Ringgold ID: RIN159223)
,
Vinka Mikulic 
2   School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina (Ringgold ID: RIN159223)
4   Department of Laboratory Diagnostics, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina (Ringgold ID: RIN159223)
,
Ivona Šušak
2   School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina (Ringgold ID: RIN159223)
3   Clinic of Gynecology and Obstetrics, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina (Ringgold ID: RIN290968)
,
Vajdana Tomic
2   School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina (Ringgold ID: RIN159223)
3   Clinic of Gynecology and Obstetrics, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina (Ringgold ID: RIN290968)
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Abstract

Objective

The objective of this prospective study was to assess the concentration and impact of maternal 25(OH)D status on neonatal vitamin D concentrations and early neonatal outcomes in the newborns of mothers who did not take vitamin D supplements during pregnancy.

Methods and participants

The study is a cohort prospective study of the correlation of VD concentrations in mothers and their newborns. The study included 100 pairs.

Results

Only 16 mothers had a VD concentration in the reference interval (75–100 nmol/L), while 84 mothers had values less than 75 nmol/L (p<0.001). A significant difference in maternal VD concentration was determined in relation to tobacco consumption habits during pregnancy and placental condition (p<0.001). 95% of the neonates (95/100) of older, obese multigravida, who had hypovitaminosis D and inadequate exposure to sunshine, had normal VD concentrations (the mean=49.27 nmol/L) on the first day of life. The majority of the mothers gave birth to full-termnewborns with normal vitality scores and CRP and bilirubin levels in the reference interval.

Conclusion

The conclusion of this prospective study is that 84% of the healthy pregnant women had hypovitaminosis D. However 95% of their newborns were born full term, with normal anthropometric measurements, normal vitality scores, and normal VD concentrations. This study also confirmed that there is still no cause-and-effect association between hypovitaminosis D in pregnant women and their offspring with outcome parameters for both.

Keywords

infants - pregnancy - hypovitaminosis D - outcome


Publikationsverlauf

Eingereicht: 30. August 2024

Angenommen nach Revision: 10. Februar 2025

Artikel online veröffentlicht:
11. März 2025

© 2025. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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