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Synlett
DOI: 10.1055/a-2544-1148
letter

Photoorganocatalytic Hydroacylation of Unactivated Olefins Utilizing Naphthaloylidenebenzimidazole (NBI) as the Catalyst

George Michael
1   Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece (Ringgold ID: RIN68993)
,
Periklis X. Kolagkis
1   Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece (Ringgold ID: RIN68993)
,
Eirini M. Galathri
1   Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece (Ringgold ID: RIN68993)
,
Christoforos G. Kokotos
1   Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece (Ringgold ID: RIN68993)
› Author AffiliationsSupported by: Hellenic Foundation for Research and Innovation 655
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Selective C–H activation is gaining prominence as a valuable strategy in synthetic chemistry. The metal-free C–H activation of aldehydes to promote the hydroacylation of electron-deficient alkenes offers a promising approach for C–C bond formation. However, achieving selectivity, particularly with α,α-disubstituted aldehydes, remains challenging. In this study, we present a green, cost-effective, and easily reproducible method for the selective hydroacylation of alkenes. This process employs naphthaloylidenebenzimidazole (NBI) as the photocatalyst under blue LED irradiation, yielding products with excellent selectivity and efficiency.



Publication History

Received: 16 January 2025

Accepted after revision: 21 February 2025

Accepted Manuscript online:
21 February 2025

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