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Am J Perinatol
DOI: 10.1055/a-2549-6551
Original Article

The non-bacterial infant microbiome and necrotizing enterocolitis

Nilima Jawale 
1   Pediatrics, SUNY Upstate Medical University Department of Pediatrics, Syracuse, United States (Ringgold ID: RIN549986)
,
Jeffrey Shenberger
2   Connecticut Children's Medical Center, Hartford, United States (Ringgold ID: RIN20425)
,
Ricardo Rodriguez
3   Pediatrics, Wake Forest University School of Medicine, Winston-Salem, United States (Ringgold ID: RIN12279)
,
Avinash k Shetty
4   Department of Pediatrics, Infectious Disease, Wake Forest University, Winston-Salem, United States (Ringgold ID: RIN8676)
,
Parvesh M. Garg
5   Department of Pediatrics, Section of Neonatology, Wake Forest University, Winston-Salem, United States (Ringgold ID: RIN8676)
› InstitutsangabenGefördert durch: National Institute of General Medical Sciences U54GM115428
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Necrotizing enterocolitis (NEC) is among the most devastating neonatal illnesses of premature infants. Although it is a disease of multifactorial etiology associated with bacterial dysbiosis, several reports of viral and some fungal infections associated with NEC have been published. Despite the abundance of viruses - primarily bacteriophages, and ‘virus-like particles’ in the normal infant gut flora, there is limited understanding of the contribution of these elements to newborn gut health and disease. This article aims to review existing evidence on normal newborn virome and mycobiome development, and present insights into the complex inter kingdom interactions between gut bacteria, viruses and fungi in the intestinal ecosystem, exploring their potential role in predisposing the preterm infant to NEC.



Publikationsverlauf

Eingereicht: 03. Januar 2025

Angenommen nach Revision: 03. März 2025

Accepted Manuscript online:
04. März 2025

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