Expanding the Scope of Azole-Based γ-Amino Acids – Synthesis and Structural Diversity

Abstract

The development of non-canonical amino acids is pivotal to peptide engineering, enabling the design of molecules with novel structural features, improved activities, and optimized metabolic profiles. Among these, heteroaromatic γ-amino acids have attracted significant attention for their ability to mimic native peptide folds while accessing novel conformational spaces. In this study, the chemical diversity of heteroaromatic γ-amino acids was expanded by introducing two new monomers, ATC* and AOC*, designed around a thiazole and an oxazole scaffold, respectively. These analogues, characterized by their tunable substitution patterns and precise stereochemical control significantly expand the well-established ATC family.

Key words

γ-amino acid - heterocycles - azole scaffold - peptide engineering - peptidomimetic - solid-phase synthesis

Publikationsverlauf

Eingereicht: 10. Januar 2025

Angenommen nach Revision: 05. März 2025

Accepted Manuscript online:
05. März 2025

Artikel online veröffentlicht:
31. März 2025

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