Organocatalyzed Glycosylation for the Stereoselective Synthesis of O/C-Glycosides

Oligosaccharides play a pivotal role in biological systems and supporting immune function due to their unique sugar structures. To better understanding the biochemical processes, it is essential to need pure and structurally well-defined oligosaccharides. Even though there has been a significant progress in the synthesis of oligosaccharides, the efficient and stereoselective synthesis of glycosidic bonds through chemical glycosylation remains a challenging task for chemists. Organocatalysis is an exciting field in chemistry that utilizes small organic molecules as catalysts to accelerate chemical reactions under sub-stoichiometric conditions. These catalysts offer advantages like environmentally friendly conditions, high selectivity, and efficiency for synthesizing complex molecules. In the last few years, organocatalyzed glycosylation has significantly progressed in carbohydrate chemistry particular to the stereoselective synthesis of oligosaccharides. This personal account describes the organocatalytic glycosylation methodologies developed by our group for activation of trichloroacetimidate donor and glycal substrates resulting in the specific formation of -or -glycosidic bonds.

Publikationsverlauf

Eingereicht: 18. März 2025

Angenommen nach Revision: 25. April 2025

Accepted Manuscript online:
25. April 2025