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DOI: 10.1055/a-2769-2826
Efficient Dibromination of Aromatics with Fe(NO3)3·9H2O/FeBr3
Authors
This work was supported by Youth Project of Yazhou Bay Innovation Institute of Hainan Tropical Ocean University (No. 2022CXYQNXM01), National Natural Science Foundation of China (22165009), the Scientific Research Foundation of the Higher Education Institutions of Hainan Province (Hnky2025ZD-16).
Abstract
A simple, efficient, and environmentally friendly methodology for the dibromination of anisoles using Fe(NO3)3·9H2O/FeBr3 at room temperature was developed. In general, anisoles bearing electron-donating or weak electron-withdrawing groups gave the dibrominated product in good to excellent yields, while anisoles bearing a strong electron-withdrawing group gave a high yield of the monobromination product. This protocol was also suitable for the bromination of 2- or 4-substituted substrates. Importantly, this protocol was also applicable for gram-scale synthesis. It is hopeful that this methodology will have great use in organic synthesis.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2769-2826.
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Publication History
Received: 04 October 2025
Accepted after revision: 09 December 2025
Accepted Manuscript online:
11 December 2025
Article published online:
20 January 2026
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)
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