Letter to the Editor concerning “Comparison of the Effects of Stirring and Standing on Chemical Reactions” by Liu et al.

Liu et al. concluded that stirring has insignificant effect on organic reaction yields. While their extensive dataset is valuable, we identify methodological concerns: (1) omission of established mixing literature, (2) experimental conditions unsuited to time-dependent mixing effects, and (3) statistical treatment potentially obscuring meaningful differences. Our reanalysis shows 3% mean yield improvement with stirring (99.7% confidence). We contextualise these findings within mixing science and highlight photochemical reactions as exceptional cases deserving further study.

Publication History

Received: 20 November 2025

Accepted after revision: 14 January 2026

Accepted Manuscript online:
16 January 2026