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Synthesis
DOI: 10.1055/a-2793-0030
Review

Recent Advances on Asymmetric Synthesis of Benzofused Six-membered Oxygen Containing Heterocyles (2020-2025)

Authors

  • Sobia Tariq

    1   Institute for Carbon-Neutral Technology, Shenzhen Polytechnic University, Shenzhen, China (Ringgold ID: RIN47891)
    2   Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China (Ringgold ID: RIN12381)

  • Arsalan Haider

    1   Institute for Carbon-Neutral Technology, Shenzhen Polytechnic University, Shenzhen, China (Ringgold ID: RIN47891)
    2   Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China (Ringgold ID: RIN12381)

  • Yu Qian

    1   Institute for Carbon-Neutral Technology, Shenzhen Polytechnic University, Shenzhen, China (Ringgold ID: RIN47891)
    3   Guangdong Basic Research Center of Excellence for Aggregate Science, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, China (Ringgold ID: RIN26451)

  • Jun Chen

    1   Institute for Carbon-Neutral Technology, Shenzhen Polytechnic University, Shenzhen, China (Ringgold ID: RIN47891)
    4   College of Chemistry and Materials Science, Hunan Agricultural University, Changsha, China (Ringgold ID: RIN12575)

  • Xueling Bai

    2   Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China (Ringgold ID: RIN12381)

  • Runtong Zhang

    1   Institute for Carbon-Neutral Technology, Shenzhen Polytechnic University, Shenzhen, China (Ringgold ID: RIN47891)

  • Baode Ma 

    1   Institute for Carbon-Neutral Technology, Shenzhen Polytechnic University, Shenzhen, China (Ringgold ID: RIN47891)

Supported by: Key Areas Research Program of Guangdong Provincial Department of Education 2024ZDZX2107,2024ZDZX3083
Supported by: Shenzhen Polytechnic University-TS Biotech Green Synthetic Cosmetics R&D Center 602531005PQ
Supported by: Shenzhen Polytechnic University-Ruijie Oxo Synthesis R&D Center 602431002PQ
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Asymmetric synthesis due to distinct physiological effects of enantiomers has been a key focus in both academic and industrial laboratories for decades, offering challenges for chemists and enabling the development of valuable pharmaceuticals and agrochemicals. Medium-ring heterocycles, particularly benzofused oxygen-containing six-membered rings such as pyrones and pyrans, represent crucial structural motifs in synthetic and natural products and drug discovery. These scaffolds exhibit significant pharmacological activities and find additional applications in materials science, as well as in the agricultural and food industries. This review summarizes the recent advances over the past five years (2020-2025) in the asymmetric synthesis of valuable scaffolds such as isocoumarins, coumarins, flavonoids/chromones and chromanes, encompassing both transition metal-catalyzed approaches and metal-free organocatalytic strategies. It highlights the principal reaction types, strategies for stereocontrol, reported yields and applications in synthesis of natural products.



Publication History

Received: 30 October 2025

Accepted after revision: 20 January 2026

Accepted Manuscript online:
20 January 2026

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