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Synthesis
DOI: 10.1055/a-2796-9980
Review

Highlights of Pd-Catalyzed Reactions of Alkynes Involving C-H Functionalization: Synthesis of Acyclic, Carbo- and Heterocyclic Compounds Installed with Alkyne Unit

Authors

  • Subhankar Bodak

    1   Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Mohali, India

  • Prashant Shukla

    1   Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Mohali, India

  • Amit Kumar

    1   Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Mohali, India

  • Srinivasarao Arulananda Babu 

    1   Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Mohali, India

Supported by: CSIR, New Delhi
Supported by: IISER Mohali
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The review discusses the utility of C-H functionalization approaches involving alkynes, which act as multifaceted coupling partners due to their unsaturation property, small size, and potential to participate in multiple reaction pathways, such as annulations, alkylation, alkenylation, and alkynylation. The review emphasises the investigation of palladium catalysis for these transformations. It highlights the developments in Pd-catalysed C-H functionalization-based synthesis of simple and complex carbo- and heterocyclic compounds, as well as biologically active and alkynyl-functionalized molecules.



Publication History

Received: 28 November 2025

Accepted after revision: 26 January 2026

Accepted Manuscript online:
27 January 2026

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