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Synlett
DOI: 10.1055/a-2798-0666
Letter

Catalyst-free Alkylation of Quinoxalines in Water

Authors

  • Jingxue Yang

    1   School of Chemistry and Chemical Engineering, Huaibei Normal University, Huaibei, China (Ringgold ID: RIN58286)

  • Rui Zhu

    1   School of Chemistry and Chemical Engineering, Huaibei Normal University, Huaibei, China (Ringgold ID: RIN58286)

  • Nuoyan Li

    1   School of Chemistry and Chemical Engineering, Huaibei Normal University, Huaibei, China (Ringgold ID: RIN58286)

  • Panpeng Wei 

    1   School of Chemistry and Chemical Engineering, Huaibei Normal University, Huaibei, China (Ringgold ID: RIN58286)

Supported by: Doctoral Research Startup Fund (Huaibei Normal University 03106282
Supported by: Open Project Funds for the Laboratory (Huaibei Normal University 2025xjsyskf036
Supported by: the Natural Science Research Project of Anhui Education Department 2025AHGXZK40568
Further Information
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A catalyst-free nucleophilic allylation of quinoxalines in water has been developed, enables efficient synthesis of versatile functionalized C3-alkylated quinoxalin-2(1H)-ones. This method selectively activates the imine moiety through hydrogen-bonding interactions, shunning conventional strategies that require transition metals, photoirradiation or elevated temperatures. Remarkably, the reaction exhibits accelerated kinetics in water, due to strong hydrogenbonding effects that facilitate reactant aggregation.



Publication History

Received: 02 November 2025

Accepted after revision: 27 January 2026

Accepted Manuscript online:
27 January 2026

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