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CC BY 4.0 · SynOpen
DOI: 10.1055/a-2816-1610
Graphical Review

Recent Advances in the Synthesis and Utility of 1,1-dibromoolefins

Authors

  • Andrew Gregory Durant 

    1   Department of Chemistry, University of Toronto, Toronto, Canada (Ringgold ID: RIN7938)

  • Lukas J Glofcheskie

    1   Department of Chemistry, University of Toronto, Toronto, Canada (Ringgold ID: RIN7938)

  • Julian K Fernback

    1   Department of Chemistry, University of Toronto, Toronto, Canada (Ringgold ID: RIN7938)

  • Arthur Flaget 

    1   Department of Chemistry, University of Toronto, Toronto, Canada (Ringgold ID: RIN7938)

  • Mark Lautens 

    1   Department of Chemistry, University of Toronto, Toronto, Canada (Ringgold ID: RIN7938)

Supported by: Natural Science and Engineering Research Council (NSERC)
Supported by: Paraza Pharma Inc
Supported by: University of Toronto
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1,1-Dibromoolefins represent an important motif for synthetic chemists. Each carbon-bromine bond represents a reactive handle that can be differentially functionalized to increase molecular complexity from simple starting materials. They can be used for the synthesis of a variety of heterocycles, densely functionalized olefins, and alkynes. Facile access to this functional group can be achieved from a corresponding carbonyl, olefin, or alkyne. The review represents a broad overview of the synthesis and synthetic utility of this important functional group since 2011. It covers their reactivity with metal catalysts as well as in metal free reactions.Key words 1,1-



Publication History

Received: 12 January 2026

Accepted after revision: 17 February 2026

Accepted Manuscript online:
20 February 2026

© . The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

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