Semin Thromb Hemost 2008; 34(3): 286-289
DOI: 10.1055/s-0028-1082273
© Thieme Medical Publishers

Neurologic Symptoms as a Feature of the Antiphospholipid Syndrome

Wolfgang Miesbach1
  • 1Medical Clinic III, Institute of Transfusion Medicine, University Hospital, Johann Wolfgang Goethe University, Frankfurt, Germany
Further Information

Publication History

Publication Date:
21 August 2008 (online)

ABSTRACT

Antiphospholipid antibodies may cause various neurologic diseases by vascular and immune mechanisms. Ischemic stroke and transient ischemic attacks are the most common neurologic complications in patients with antiphospholipid antibodies but migraine, epilepsy, chorea, or multiple sclerosis also may occur. Although the neurologic presentation of patients with the antiphospholipid syndrome may vary, many patients have striking similarities, such as initial memory loss, aphasia, cognitive dysfunction with progressive cerebral deterioration, and even dementia. In conclusion, antiphospholipid syndrome may constitute a treatable cause of neurologic diseases, and the measurement of antiphospholipid antibodies should be routinely performed in patients with neurologic disorders.

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Wolfgang MiesbachM.D. 

Medical Clinic III, Institute of Transfusion Medicine, Johann Wolfgang Goethe University

Frankfurt/Main, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany

Email: wolfgang.miesbach@kgu.de