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Synthesis 2008(21): 3492-3496
DOI: 10.1055/s-0028-1083178
DOI: 10.1055/s-0028-1083178
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Regiospecific Bromination of 2-Phenyl-3H-pyrimidin-4-ones
Further Information
Publication History
Received
11 June 2008
Publication Date:
16 October 2008 (online)
Abstract
Three methods for the regiospecific bromination of 2-phenyl-3H-pyrimidin-4-ones are presented: bromination of the 5-position of the pyrimidine ring, bromination of the 6-benzylic position and simultaneous bromination of both the 5-position of the pyrimidine ring and 6-benzylic position. Reactions were carried out using simple protocols and the brominated pyrimidines were obtained in good yields.
Key words
enones - bromination - bromopyrimidines - pyrimidin-4-ones - 2-phenyl-pyrimidin-4-ones