tert-Butoxycarbonyl
Chloride for the Introduction of N-Boc
Groups into Amino Acids

Helmut Vorbrüggen

doi:10.1055/s-0028-1083227

SHORTPAPER

tert-Butoxycarbonyl Chloride for the Introduction of N-Boc Groups into Amino Acids

Helmut Vorbrüggen*^a,b
^a (The Former) Woodward Research Institute, 4000 Basel, Switzerland
^b Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany
e-Mail: helvor@chemie.fu-berlin.de;

Abstract

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Abstract

tert-Butoxycarbonyl chloride (BocCl) can be generated in situ from tert-butyl alcohol, COCl₂, and pyridine at -74 ˚C to introduce the Boc group in high yield into a hindered amino acid. The method is suitable for large-scale preparations of Boc-amino acids.

Key words

Boc chloride - COCl₂ - pyridine - mixed anhydrides - amino acids

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Referenzen

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