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Synthesis 2008(24): 3974-3980
DOI: 10.1055/s-0028-1083245
DOI: 10.1055/s-0028-1083245
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Copper(I) Iodide Catalyzed Domino Process to Quinazolin-4(3H)-ones
Further Information
Received
22 August 2008
Publication Date:
01 December 2008 (online)
Publication History
Publication Date:
01 December 2008 (online)
![](https://www.thieme-connect.de/media/synthesis/200824/lookinside/thumbnails/10.1055-s-0028-1083245-1.jpg)
Abstract
An efficient synthesis of substituted quinazolin-4(3H)-ones by a one-pot ligand-free CuI-catalyzed coupling/condensative cyclization under mild conditions is described. Our study provides an alternative strategy for the preparation of biologically active quinazolin-4(3H)-ones.
Key words
quinazolin-4(3H)-ones - one-pot - ligand-free - copper(I) iodide - coupling/condensative cyclization
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References
CCDC # 701749 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge at www.ccdc.cam.ac.uk/conts/retrieving.html [or from the Cambridge Crystallographic Data Centre, 12, Union Road, Cambridge CB2 1EZ, UK; fax: +44(1223)336033; E-mail: deposit@ccdc.cam.ac.uk].