Pd/Cu-Catalyzed Oxidative
C-H Alkenylation of Imidazo[1,2-a]pyridines

Jamal Koubachi; Sabine Berteina-Raboin; Abderrahim Mouaddib; Gérald Guillaumet

doi:10.1055/s-0028-1083252

PAPER

Pd/Cu-Catalyzed Oxidative C-H Alkenylation of Imidazo[1,2-a]pyridines

Jamal Koubachi^a,b, Sabine Berteina-Raboin*^a, Abderrahim Mouaddib^b, Gérald Guillaumet^a
^a Institut de Chimie Organique et Analytique, UMR CNRS 6005, Université d’Orléans, BP 6759, 45067 Orléans Cedex 2, France
Fax: +33(2)38417281; e-Mail: sabine.berteina-raboin@univ-orleans.fr;
^b Faculté des Sciences et Techniques de Beni-Mellal, Université Sultan Moulay Slimane, BP 523, 23000 Beni-Mellal, Morocco

Abstract

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Abstract

A novel direct and regioselective Pd/Cu-catalyzed intermolecular oxidative coupling of imidazo[1,2-a]pyridines with alkenes was successfully developed. The scope and limitations of the reaction were further studied by using various alkenes. This method provides a ‘green’ route to 3-alkenylimidazo[1,2-a]pyridine derivatives in high yields.

Key words

palladium/copper-catalyzed oxidative coupling - alkenylation - imidazo[1,2-a]pyridines

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