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Synthesis 2009(3): 502-507
DOI: 10.1055/s-0028-1083294
DOI: 10.1055/s-0028-1083294
PSP
© Georg Thieme Verlag
Stuttgart ˙ New York
2-Oxazol-5-ylethanones by Consecutive Three-Component Amidation-Coupling-Cycloisomerization (ACCI) Sequence
Weitere Informationen
Received
4 September 2008
Publikationsdatum:
19. Dezember 2008 (online)
Publikationsverlauf
Publikationsdatum:
19. Dezember 2008 (online)
![](https://www.thieme-connect.de/media/synthesis/200903/lookinside/thumbnails/10.1055-s-0028-1083294-1.jpg)
Abstract
Substituted oxazol-5-ylethanones can be synthesized in a consecutive three-component sequence starting from propargylamine and various acid chlorides, both for amidation and cross-coupling. Therefore, this diversity-oriented one-pot approach to substituted oxazoles can be considered as an amidation-coupling-cycloisomerization (ACCI) sequence.
Key words
C-C coupling - catalysis - cycloisomerization - multi-component reactions - oxazoles
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