A Simple and Efficient Preparation of Novel Formaldehyde Derivatives

Abstract

New formaldehyde derivatives were prepared in good yields by a short and versatile route. Several crystal structures of corresponding thioacetic acid esters and thiols were determined. The thioacetates were cleaved under acidic or basic conditions affording the thiols in high yield, thus introducing the new substance classes of N-mercaptomethyl-alkylcarboxamides, N-mercapto­methylsulfonamides, and alkoxymethanethiols.

Key words

N-mercaptomethylcarboxamides - N-mercaptomethylsulfonamides - methoxymethanethiol

References

• 1 Pfaendler HR. inventors; US Patent  6482818.  ; Chem. Abstr. 2000, 132, 137202
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CCDC 678213 (4b), CCDC 694690 (4i), CCDC 678214 (4j), CCDC 694363 (5d), CCDC 694364 (5g), CCDC 694362 (5h) and CCDC 694365 (5i) contain the supplementary crystallographic data for this paper. These data can be obtained free of charge from Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/­
data_request/cif or from the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: [phone]; e-mail: [e-mail].