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Synthesis 2009(3): 399-402
DOI: 10.1055/s-0028-1083313
DOI: 10.1055/s-0028-1083313
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Nucleophilic Addition of 4-Hydroxycoumarin to Baylis-Hillman Acetate Adducts
Further Information
Received
27 August 2008
Publication Date:
09 January 2009 (online)
Publication History
Publication Date:
09 January 2009 (online)
![](https://www.thieme-connect.de/media/synthesis/200903/lookinside/thumbnails/10.1055-s-0028-1083313-1.jpg)
Abstract
The exploration of 4-hydroxycoumarin for nucleophilic addition on to Baylis-Hillman acetate adducts has been described for the first time. The reactions of various Baylis-Hillman acetate adducts were examined with 4-hydroxycoumarins in the presence of base to produce the corresponding 3-substituted 4-hydroxycoumarins in good yields.
Key words
Baylis-Hillman adduct - hydroxycoumarin - nucleophilic addition - 3-substituted coumarin - potassium carbonate
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