Synthesis of bis-fused benzofuran derivatives by the implementation
of palladium-mediated intramolecular cyclization is described. To
our knowledge, this is the first report of the synthesis of bis-fused
benzofuran by this protocol. Bisbenzoxepine and bisbenzoxocine derivatives
were also synthesized by the application of two-directional ring-closing
metathesis.
palladium catalyst - Grubbs catalyst - intramolecular
cyclization - two-directional ring-closing metathesis - 5-exo-trig
- benzofuran - oxepine - oxocine
