Efficient Synthesis of Substituted
Cyclic α-Aminophosphonates

Irina L. Odinets; Oleg I. Artyushin; Nikolay Shevchenko; Pavel V. Petrovskii; Valentin G. Nenajdenko; Gerd-Volker Röschenthaler

doi:10.1055/s-0028-1083349

PAPER

Efficient Synthesis of Substituted Cyclic α-Aminophosphonates

Irina L. Odinets*^a, Oleg. I. Artyushin^a, Nikolay Shevchenko^b, Pavel V. Petrovskii^a, Valentin G. Nenajdenko^b, Gerd-Volker Röschenthaler^c
^a A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilova Street, 119991 Moscow, Russian Federation
Fax: +7(499)1355085; e-Mail: odinets@ineos.ac.ru;
^b Moscow State University, Leninskie Gory, 119992 Moscow, Russian Federation
^c Institute of Inorganic and Physical Chemistry, University of Bremen, Leobener Str., 28334 Bremen, Germany

Abstract

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Abstract

The addition of diethyl phosphite to cyclic imines bearing alkyl, aryl, or heteroaryl substituents at the α-position in diethyl ether at room temperature presents an efficient route to substituted cyclic α-aminophosphonates. The application of boron trifluoride-diethyl ether complex as a catalyst significantly accelerates the reaction.

Key words

diethyl phosphonate - cyclic imines - addition reactions - α-aminophosphonates

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