Semin Thromb Hemost 2008; 34(4): 335-339
DOI: 10.1055/s-0028-1085475
© Thieme Medical Publishers

Antiprothrombin Antibody Testing: Detection and Clinical Utility

Kenji Oku1 , Tatsuya Atsumi1 , Olga Amengual1 , Takao Koike1
  • 1Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Further Information

Publication History

Publication Date:
23 September 2008 (online)

ABSTRACT

Anticardiolipin antibody (aCL), anti-β2 glycoprotein I antibodies, and lupus anticoagulant (LA) are the only laboratory tests considered within the revised criteria for the classification of the antiphospholipid syndrome (APS). Recently, antibodies against phosphatidylserine-prothrombin complex (aPS/PT) have been detected, and these antibodies, rather than antibodies against prothrombin alone, are closely associated with APS and LA. The sensitivity and specificity of aPS/PT for the diagnosis of APS were assessed in a population of patients with a variety of autoimmune disorders. aCL and aPS/PT have similar diagnostic value for APS, therefore aPS/PT should be further explored, not only for research purposes but also as a candidate for one of the laboratory criteria for the classification of the APS.

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Dr. Tatsuya Atsumi

Department of Medicine II, Hokkaido University Graduate School of Medicine

N15 W7, Kita-ku, Sapporo 060-8638, Japan

Email: at3tat@med.hokudai.ac.jp