Synlett 2009(3): 403-406  
DOI: 10.1055/s-0028-1087529
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Efficient Multicomponent Synthesis of α-Trifluoromethyl Proline, Homoproline, and Azepan Carboxylic Acid Dipeptides

Anton V. Gulevicha, Nikolay E. Shevchenkoa, Elisabeth S. Balenkovaa, Gerd-V. Röschenthaler*b, Valentine G. Nenajdenko*a
a Department of Chemistry, Moscow State University, Leninskije Gory, 119992 Moscow, Russian Federation
Fax: +7(495)9328846; e-Mail: nen@acylium.chem.msu.ru;
b Institute of Inorganic and Physical Chemistry, University of Bremen, Leobener Str., 28334 Bremen, Germany
Fax: +49(421)2184267; e-Mail: gvr@chemie.uni-bremen.de;
Further Information

Publication History

Received 22 August 2008
Publication Date:
21 January 2009 (online)

Abstract

Cyclic imines bearing CF3 and C2F5 group were successfully used for the first Ugi multicomponent synthesis of polyfluoroalkyl-substituted proline, homoproline, and azepan carboxylic acid derivatives. Based on the suggested reaction the first synthesis of dipeptides containing α-CF3 cyclic amino acids residue was described. The scope and limitations of the approach are discussed.

    References and Notes

  • 1a Renner C. Alefelder S. Bae JH. Budisa N. Huber R. Moroder L. Angew. Chem. Int. Ed.  2001,  40:  923 
  • 1b Improta R. Benzi C. Barone V. J. Am. Chem. Soc.  2001,  123:  12568 
  • 1c Golbik R. Yu C. Weyher-Stingl E. Huber R. Moroder L. Budisa N. Schiene-Fischer C. Biochemistry  2005,  44:  16026 
  • 2 Chen L. Kim YM. Kucera DJ. Harrison KE. Bahmanyar S. Scott JM. Yazbeck D. J. Org. Chem.  2006,  71:  5368 
  • 3 Wu W.-J. Raleigh DP. J. Org. Chem.  1998,  63:  6689 ; and references therein
  • 4 Chaume G. Van Severen M.-C. Marinkovic S. Brigaud T. Org. Lett.  2006,  8:  6123 
  • 5 Shevchenko NE. Nenajdenko VG. Röschenthaler G.-V. J. Fluorine Chem.  2008,  129:  390 
  • 6a Osipov SN. Bruneau C. Picquet M. Kolomiets AF. Dixneuf PH. Chem. Commun.  1998,  2053 
  • 6b Osipov SN. Artyushin OI. Kolomiets AF. Bruneau C. Picquet M. Dixneuf PH. Eur. J. Org. Chem.  2001,  3891 
  • 6c Eckert M. Monnier F. Thchetnikov GT. Titanyuk ID. Osipov SN. Toupet L. Dérien S. Dixneuf PH. Org. Lett.  2005,  7:  3741 
  • 7a Moldeni M. Pesenti C. Sani M. Volonterio A. Zanda M. J. Fluorine Chem.  2004,  125:  1735 
  • 7b Koksch B. Sewald N. Hofmann H.-J. Burger K. Jakubke H.-J. J. Pept. Sci.  1997,  3:  157 
  • 8a Druzhinin SV. Balenkova ES. Nenajdenko VG. Tetrahedron  2007,  63:  7753 
  • 8b Zanda M. New J. Chem.  2004,  28:  1401 
  • 8c Jäckel C. Koksch B. Eur. J. Org. Chem.  2005,  4483 
  • 9a Hodgson DRW. Sanderson JM. Chem. Soc. Rev.  2004,  33:  422 
  • 9b Thust S. Koksch B. Tetrahedron Lett.  2004,  45:  1163 
  • 10 Kobsev SP. Soloshonok VA. Yagupol’skii YuL. Kukhar’ VP. J. Gen. Chem. USSR  1989,  59:  801 
  • 11 Nagai T. Nishioka G. Koyama M. Ando A. Mild T. Kumadaki I. J. Fluorine Chem.  1992,  57:  229 
  • 12 Nenajdenko VG. Gulevich AV. Balenkova ES. Tetrahedron  2006,  62:  5922 
  • 13 Gulevich AV. Shevchenko NE. Balenkova ES. Röschenthaler G.-V. Nenajdenko VG. Tetrahedron  2008,  64:  11706 
14

The CF3-imines 1a,c,e were prepared using a standard Claisen condensation and subsequent decarboxylation, details will be published in due course.
Synthesis of 2- CF3 Pyrroline (1a)
The stirred suspension of 60% NaH (26.7 g 0.665 mol) in anhyd THF (250 mL) was heated at reflux while a mixture of freshly distilled N-vinylpyrrolidin-2-one (55.0 g, 0.50 mol) and ethyl trifluoroacetate (78.0 g, 0.55 mol) was slowly added. After refluxing for an additional hour the reaction mixture was cooled to r.t. and carefully diluted with solution of AcOH (40 g) in H2O (100 mL). The organic layer was separated and the solution of crude keto lactam product was slowly added to 6 N HCl (0.5 L) under stirring and heating at reflux. THF was removed during the addition by use of the distilling head. After heating at reflux for 60 h the reaction mixture was cooled to 0 ˚C, made basic to pH 12 by using 50% KOH aq and extracted with Et2O (4 × 100 mL). The combined organic layers were dried over K2CO3 and concentrated under atmospheric pressure to give 73 g of crude cyclic hemi-aminal product as an oil that solidified under cooling. To remove H2O the cyclic hemi-aminal was distilled at atmospheric pressure to the receiving flask charged with anhyd Na2SO4 (20 g). The drying agent was removed by filtration to afford 54.0 g (79% yield) of product as a clear, colorless liquid. ¹H NMR (200 MHz, CDCl3): δ = 1.97-2.12 (m, 2 H), 2.70-2.78 (m, 2 H), 3.98-4.08 (m, 2 H). ¹9F NMR (188 MHz, CDCl3): δ = -71.4 (s, 3 F). ¹³C NMR (100 MHz, CDCl3): δ = 124.9 (q, J = 285.4 Hz, CF3), 115.9 (q, J = 35.4 Hz), 62.2, 33.7, 22.6. HRMS (EI): m/z calcd for C5H6F3N: 137.0452; found: 137.0462.

15

General Procedure for the Ugi Reaction
The imine (1 mmol) was dissolved in CH2Cl2 (10 mL) and TFA (1 mmol), then isocyanide was added at -20 ˚C. The mixture was stirred for 12 h and treated with a mixture of EtOH-HCl aq (10:1, 0.5 mL) to remove any remaining isocyanide. The solvent was evaporated, and the residue was purified by column chromatography (hexane-EtOAc,4:1).

16

Selected Analytical Data
Compound 2a: yield 80%; colorless oil; R f = 0.8 (hexanes-EtOAc, 3:1). ¹H NMR (200 MHz, CDCl3): δ = 1.36 (s, 9 H), 1.97-2.63 (m, 2 H), 2.25-2.60 (m, 2 H), 3.67-3.85 (m, 1 H), 3.90-4.07 (m, 1 H), 6.00 (br s, 1 H) ppm. ¹9F NMR (188 MHz, CDCl3): δ = -73.7 (s, 3 F), -69.1 (s, 3 F) ppm. ¹³C NMR (100 MHz, CDCl3): δ = 163.4, 156.1 (m), 124.9 (q, J = 285.4 Hz, CF3), 115.9 (q, J = 288.4 Hz, CF3), 52.4, 49.6 (m), 33.8, 28.3, 23.8 ppm. HRMS (EI): m/z calcd for C12H16F6N2O2: 334.1116; found: 334.1112.
Compound 2c: yield 61%; white solid, mp 55-57 ˚C; R f = 0.8 (hexanes-EtOAc, 3:1). ¹H NMR (200 MHz, CDCl3): δ = 1.35 (s, 9 H), 2.00-2.19 (m, 2 H), 2.38-2.55 (m, 2 H), 3.50-3.75 (m, 1 H), 3.90-4.20 (m, 1 H), 6.1 (br s, 1 H) ppm. ¹9F NMR (188 MHz, CDCl3): δ = -73.8 (s, 3 F), -80.5 (s, 3 F), -106.2, -107.7, -109.0, -110.5 (AB system, δA = -109.3 ppm, δB = -107.4 ppm, ² J AB = 275.9 Hz, 2 F) ppm. HRMS (EI): m/z calcd for C13H16F8N2O2: 384.1084; found: 384.1080.
Compound 2g: yield 70%; white solid; mp 121-123 ˚C; R f = 0.8 (hexanes-EtOAc, 3:1). ¹H NMR (200 MHz, CDCl3): δ = 1.68-1.87 (m, 3 H), 1.94-2.17 (m, 2 H), 2.31-2.55 (m, 1 H), 3.38 (t, J = 14.7 Hz, 1 H), 3.82-4.11 (m, 1 H), 4.40-4.68 (m, 2 H), 6.0 (br s, 1 H), 6.86 (d, J = 8.6 Hz), 7.19-7.43 (m, 5 H) ppm. ¹9F NMR (188 MHz, CDCl3): δ = -71.2 (s, 3 F), -80.6 (s, 3 F), -106.2, -107.7, -109.6, -111.1 (AB system, δA =
-110.0 ppm, δB = -107.4 ppm, ² J AB = 281.1 Hz, 2 F) ppm. HRMS (EI): m/z calcd for C17H16F8N2O2: 432.1084; found: 432.1102.
Compound 2i: yield 59%; colorless oil; R f = 0.8 (hexanes-EtOAc, 3:1). ¹H NMR (400 MHz, CDCl3): δ = 1.25-1.30 (m, 1 H), 1.36 (s, 9 H), 1.66-1.90 (m, 3 H), 1.90-2.00 (m, 1 H), 2.05-2.17 (m, 2 H), 2.23-2.33 (m, 1 H), 3.20-3.30 (m, 1 H), 3.90-4.00 (m, 1 H), 5.40 (br s)ppm. ¹9F NMR (188 MHz, CDCl3): δ = -69.8 (s, 3 F), -70.1 (s, 3 F) ppm. ¹³C NMR (100 MHz, CDCl3): δ = 162.1, 157.4 (q, J = 35.9 Hz), 125.9 (q,
J = 289.8 Hz), 116.3 (q, J = 288.3 Hz), 70.2 (q, J = 24.9 Hz), 52.0, 46.2, 33.0, 30.5, 28.6, 22.3, 28.3 ppm. HRMS (EI): m/z calcd for C14H20F6N2O2: 362.1429; found: 362.1433.
Compound 4b (mixture of diastereomers, ca. 1:1): yield 60%; yellow oil; R f = 0.6 (hexanes-EtOAc, 3:1). ¹H NMR (200 MHz, CDCl3): δ = 1.24, 1.25 (dt, J = 6.9 Hz, 3 H), 1.90-2.15 (m, 2 H), 2.26-2.50 (m, 2 H), 3.10-3.22 (m, 2 H), 3.65-3.85 (m, 1 H), 3.89-4.04 (m, 1 H), 4.09-4.30 (m, 2 H), 4.80-4.95 (m, 1 H) 6.6 (br s, 1 H), 7.00-7.35 (m, 5 H) ppm. ¹9F NMR (188 MHz, CDCl3): δ = -69.2 (s, 3 F), -73.6, -73.7 (ds, 3 F) ppm. ¹³C NMR (100 MHz, CDCl3): δ = 170.6, 170.5, 164.1, 163.9, 155.4 (q, J = 34.4 Hz), 135.3, 135.2, 129.3, 129.2, 128.4, 127.1, 121.7, 121.6 (dq, J = 286.6 Hz), 118.8 (q, J = 277.6 Hz), 72.7 (m), 61.7, 61.6, 53.7, 53.5, 49.5, 37.5, 37.3, 33.8, 33.7, 23.6, 13.8 ppm. HRMS (EI): m/z calcd for C19H20F6N2O4: 454.1327; found: 454.1333.
Compound 4f (mixture of diastereomers, ca. 1:1): yield 53%; yellow oil; R f = 0.6 (hexanes-EtOAc, 3:1). ¹H NMR (200 MHz, CDCl3): δ = 1.27 (t, J = 7.3 Hz, 3 H), 1.40-1.55 (m, 3 H), 1.97-2.25 (m, 2 H), 2.45-2.70 (m, 2 H), 3.60-3.81 (m, 1 H), 4.00-4.40 (m, 3 H), 4.45-4.70 (m, 1 H), 6.00, 7.50 (br ds, 1 H) ppm. ¹9F NMR (188 MHz, CDCl3): δ = -73.2,
-73.3 (ds, 3 F), -79.8, -80.0 (ds, 3 F), -105.5, -107.0, -107.6, -108.7 (AB system, δA = -108.3 ppm, δB = -106.3 ppm, ² J AB = 277.6 Hz), -106.0, -107.4, -109.0, -110.2 (AB system, δA = -109.2 ppm, δB = -107.2 ppm, ² J AB = 277.6 Hz)ppm. ¹³C NMR (100 MHz, CDCl3): δ = 172.3, 172.1, 163.9, 163.8, 156.8, 115.9 (q, J = 286.9 Hz), 108.0-126.0 (unresolved signals, C2F5 group), 72.7 (m), 61.8, 61.7, 49.7 (m), 49.1, 34.1, 23.1, 17.8, 17.7, 14.0 ppm. HRMS (EI): m/z calcd for C14H16F8N2O4: 428.0982; found: 428.0978.
Compound 4i (mixture of diastereomers, ca. 1:1): yield 44%; colorless oil; R f = 0.6 (hexanes-EtOAc, 3:1). ¹H NMR (200 MHz, CDCl3): δ = 1.28 (t, J = 7.3 Hz, 3 H), 1.70-1.95 (m, 4 H), 2.05-2.40 (m, 6 H), 2.40-2.55 (m, 2 H), 3.35-3.60 (m, 1 H), 3.85-4.10 (m, 1 H), 4.21 (q, J = 7.3 Hz, 2 H), 4.53-4.70 (m, 1 H), 6.55-6.80 (m, 1 H) ppm. ¹9F NMR (188 MHz, CDCl3): δ = -68.05, -68.41 (ds, 3 F), -70.0, -70.1 (ds, 3 F) ppm. ¹³C NMR (100 MHz, CDCl3): δ = 171.4, 171.3, 164.5, 164.0, 157.0 (m), 125.3, 125.1 (dq, J = 289.8 Hz), 115.9 (q, J = 287.6 Hz), 66.3 (m), 61.8, 52.2, 42.0, 41.7, 30.9, 30.6, 29.7, 29.5, 28.2, 27.7, 21.5, 21.3, 15.2, 15.2, 15.1, 15.0, 13.9 ppm. HRMS (EI): m/z calcd for C16H22F6N2O4S: 452.1205; found: 452.1220.
Compound 4k (mixture of diastereomers, ca. 1:1): yield 50%; colorless oil; R f = 0.6 (hexanes-EtOAc, 3:1). ¹H NMR (200 MHz, CDCl3): δ = 1.20-1.35 9m, 3 H), 1.44 (t, J = 7.3 Hz, 3 H), 1.70-1.87 (m, 3 H), 1.90-1.25 (m, 2 H), 2.30-2.50 (m, 1 H), 3.20-3.50 (m, 1 H), 3.80-4.00 (m, 1 H), 4.10-4.30 (m, 2 H), 4.45-4.68 (m, 1 H), 6.6, 6.2 (br ds, 1 H) ppm. ¹9F NMR (188 MHz, CDCl3): δ = -70.6, -70.5 (ds, 3 F), -79.9, -79.8 (ds, 3 F), -106.2, -107.7, -109.7, -111.2 (AB system, δA = -110.0 ppm, δB = -107.4 ppm, ² J AB = 277.6 Hz),
-106.3, -107.8, -109.5, -111.0 (AB system, δA = -109.8 ppm, δB = -107.5 ppm, ² J AB = 277.6 Hz)ppm. ¹³C NMR (100 MHz, CDCl3): δ = 172.5, 172.3, 162.7, 162.6, 157.5 (q, J = 36.6 Hz), 116.0 (q, J = 287.6 Hz), 111.0-124.0 (unresolved signals, C2F5 group), 67.9 (m), 61.8, 61.7, 49.0, 48.9, 48.8 (m), 26.8, 26.3, 20.3, 30.2, 18.0, 17.7, 14.3, 14.2, 13.9, 13.8 ppm. HRMS (EI): m/z calcd for C15H18F8N2O4: 442.1139; found: 442.1133.
Compound 4l˙H2O: yield 54%; colorless oil; R f = 0.6 (hexanes-EtOAc, 3:1). ¹H NMR (200 MHz, CDCl3): δ = 1.30 (t, J = 7.1 Hz), 1.55-1.65 (m, 1 H), 1.80-2.05 (m, 4 H), 2.50-2.70 (m, 1 H), 3.00-3.15 (m, 1 H), 3.60-3.70 (m, 1 H), 4.02 (d, J = 18.0 Hz, 1 H), 4.25 (q, J = 7.1 Hz, 2 H), 4.54 (q, J = 18.0 Hz, 1 H), 4.9 (br s, 1 H) ppm. ¹9F NMR (188 MHz, CDCl3): δ = -77.3 (q, J = 9.7 Hz, 3 F), -80.4 (q, J = 9.7 Hz, 3 F) ppm. ¹³C NMR (100 MHz, CDCl3): δ = 172.0, 169.6, 169.1, 124.6 (q, J = 288.4 Hz), 122.4 (q, J = 291.3 Hz), 96.5 (q, J = 34.4 Hz), 70.2 (m), 60.3, 44.0, 42.7 (m), 32.6, 30.0, 29.9, 22.5, 13.9 ppm. HRMS (EI): m/z calcd for C13H16F6N2O4: 378.1014; found: 378.1000.