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Synthesis 2009(7): 1131-1136
DOI: 10.1055/s-0028-1088004
DOI: 10.1055/s-0028-1088004
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Three-Component Coupling of Isoquinoline, Activated Alkyne and Nitromethane: A Facile Synthesis of Nitromethyl Derivatives of 1,2-Dihydroisoquinolines
Further Information
Received
10 November 2008
Publication Date:
06 March 2009 (online)
Publication History
Publication Date:
06 March 2009 (online)
![](https://www.thieme-connect.de/media/synthesis/200907/lookinside/thumbnails/10.1055-s-0028-1088004-1.jpg)
Abstract
A three-component coupling (3CC) of isoquinoline, activated alkynes and nitromethane has been achieved for the first time to produce nitromethyl derivatives of dihydroisoquinoline in excellent yields with high selectivity. The reaction proceeds smoothly at 25 ˚C without catalyst.
Key words
aza-Henry reaction - isoquinoline/quinoline - activated alkynes - nitromethane
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