Preparation of 9-Substituted
Pyridine-Stretched Adenines and Hypoxanthines

Julia A. Crawford; William Fraser; Christopher A. Ramsden

doi:10.1055/s-0028-1088028

PAPER

Preparation of 9-Substituted Pyridine-Stretched Adenines and Hypoxanthines

Julia A. Crawford^a, William Fraser^b, Christopher A. Ramsden*^a
^a Lennard-Jones Laboratories, School of Physical and Geographical Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK
Fax: +44(1782)712378; e-Mail: c.a.ramsden@chem.keele.ac.uk;
^b School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK

Abstract

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Abstract

9-Methylsulfanyl pyridine-stretched adenine and hypoxanthine derivatives have been prepared via regioselective reaction of a 5-aminoimidazole with 2-(bis-methylsulfanylmethylene)malononitrile [(NC)₂C=C(SMe)₂]. The 9-methylsulfanyl substituent can be replaced by sequential oxidation and substitution by nucleophiles including amines.

Key words

5-aminoimidazoles - lin-pyridoadenines - soft electrophiles - tricyclic heterocycles - pyridine-stretched purines

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References

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