Dendrimers of Vaccines Consisting of Tumor-Associated Glycopeptide Antigens and T Cell Epitope Peptides

Abstract

According to the principle of multiple antigen presentation (MAP), a di-lysyl lysine core was used for the synthesis of tetramers of a glycododecapeptide antigen from the tandem-repeat sequence of the tumor-associated mucin, MUC1, which carries a sialyl T_N-antigen saccharide side chain. The methodology was extended to the analogous construction of a tetrameric vaccine consisting of a T cell epitope from tetanus toxoid and the sialyl T_N-glycododecapeptide of MUC1.

Key words

tumor-associated antigens - glycopeptides - fragment condensation - MUC1 - multiple antigen presentation

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