According to the principle of multiple antigen presentation (MAP),
a di-lysyl lysine core was used for the synthesis of tetramers of
a glycododecapeptide antigen from the tandem-repeat sequence of
the tumor-associated mucin, MUC1, which carries a sialyl TN-antigen
saccharide side chain. The methodology was extended to the analogous
construction of a tetrameric vaccine consisting of a T cell epitope
from tetanus toxoid and the sialyl TN-glycododecapeptide
of MUC1.
tumor-associated antigens - glycopeptides - fragment condensation - MUC1 - multiple antigen presentation
