Abstract
A series of 1,6-naphthyridines and pyrano[3,2-c ]pyridines were selectively
synthesized via microwave-assisted reactions controlled by the nature
of the solvent. This has resulted in an efficient and promising
synthetic method for constructing the 1,6-naphthyridine and pyrano[3,2-c ]pyridine skeletons.
Key words
solvent-dependent chemoselectivity - 1,6-naphthyridines - pyrano[3,2-c ]pyridines
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10 The single-crystal growth was carried
out in ethanol at room temperature. X-ray crystallographic analysis
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Crystal data for 4i : empirical formula = C25 H20 N4 S2 ,
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mm, monoclinic, space group P 2(1)/n , a = 11.0619(12) Å, b = 11.2598(13) Å, c = 17.5329(19) Å, α = 90, β = 93.6620(10), γ = 90, µ = 0.265
mm-¹ , V = 2179.3(4) ų , Z = 4, D
c
= 1.343
g/cm³ , F(000) = 920, S = 0.808, R
1 = 0.0665, wR
2 = 0.0863.
