Orthogonally N-protected (Boc and Cbz) 3,4-aziridinopiperidine
is a versatile building block for the synthesis of 4-substituted
3-aminopiperidines, which are compounds with a high potential for
biological activity. A multigram synthesis over five steps, starting
with extraordinarily simple materials (pyridine and benzyl chloride),
was developed.
amines - piperidines - aziridines - building
blocks - protective groups