Abstract
It was found that the zwitterionic intermediate obtained from
the addition of isocyanides to dimethyl acetylenedicarboxylate could
react with 1,3-dipolar compounds under mild conditions to produce
5-imino-2,3,5,8-tetrahydropyrazolo[1,2-a ]pyridazin-1-one derivatives
in high yields. A plausible mechanism was also discussed for this
process.
Key words
isocyanide - dimethyl acetylenedicarboxylate - multicomponent
reactions - 1,3-dipolar compounds - 5-imino-2,3,5,8-tetrahydropyrazolo[1,2-a ]pyridazin-1-one
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