Planta Med 2008; 74(13): 1625-1634
DOI: 10.1055/s-0028-1088306
Review
© Georg Thieme Verlag KG Stuttgart · New York

Chokeberry (Aronia melanocarpa) – A Review on the Characteristic Components and Potential Health Effects

Sabine E. Kulling1 , Harshadai M. Rawel1
  • 1Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, Nuthetal (OT Bergholz-Rehbrücke), Germany
Weitere Informationen

Publikationsverlauf

Received: May 19, 2008 Revised: August 18, 2008

Accepted: August 28, 2008

Publikationsdatum:
20. Oktober 2008 (online)

Abstract

The intention of this review is to contribute to a better understanding of the potentials of the nutritional contribution of Aronia berries (Aronia melanocarpa). The paper gives a short background to their botanical classification and cultivation practice, going in detail to describe the chemical composition of the berries. The emphasis is laid thereby upon the phenolic constituents. The paper finally gives a short resume of their beneficial effects in biological systems in vitro, in animals, and in humans, thus underlining their medicinal potential.

References

  • 1 Seidemann J. Chokeberries a fruit little-known till now.  Dtsch Lebensmitt Rundsch. 1993;  89 149-51
  • 2 Strigl A W, Leitner E, Pfannhauser W. Die schwarze Apfelbeere (Aronia melanocarpa) als natürliche Farbstoffquelle.  Dtsch Lebensmitt Rundsch. 1995;  91 177-80
  • 3 Hardin J W. The enigmatic chokeberries (Aronia, Rosaceae).  Bull Torrey Bot Club. 1973;  100 178-84
  • 4 Hukkanen A T, Polonen S S, Karenlampi S O, Kokko H I. Antioxidant capacity and phenolic content of sweet rowanberries.  J Agric Food Chem. 2006;  54 112-9
  • 5 Jeppsson N. The effect of cultivar and cracking on fruit quality in black chokeberry (Aronia melanocarpa) and hybrids between chokeberry and rowan (Sorbus).  Gartenbauwissenschaft. 2000;  65 93-8
  • 6 Lehmann H. About the aptitude of the black rowanberries (Aronia melanocarpa) for industrial processing.  Lebensmittelindustrie. 1982;  29 175-7
  • 7 McKay S A. Demand increasing for aronia and elderberry in North America. Available at http://www.fruit.cornell.edu/Berries/specialtyfru %20pdf/aroniaeldeberry.pdf. Accessed April 19, 2008. (Reprinted from: New York Berry News, Vol. 3 No. 11, March 17, 2004.) 
  • 8 Ara V. Schwarzfruchtige Aronia: Gesund – und bald ”in aller Munde”?.  Flüssiges Obst. 2002;  10 653-8
  • 9 Lehmann H. Die Aroniabeere und ihre Verarbeitung.  Flüssiges Obst. 1990;  57 746-52
  • 10 Scott R W, Skirvin R M. Black chokeberry (Aronia melanocarpa Michx.): A semi-edible fruit with no pests.  J Am Pomol Soc. 2007;  61 135-7
  • 11 Jeppsson N, Johansson R. Changes in fruit quality in black chokeberry (Aronia melanocarpa) during maturation.  J Hortic Sci Biotechnol. 2000;  75 340-5
  • 12 Fan-Yung A F, Rechits M A. Veränderungen der chemischen Zusammensetzung von Apfelbeeren während der Lagerung und Verarbeitung; Nachrichten höhere Lehranstalten Krasnodar.  Izv Vyssh Uchebn Zaved, Pishch Tekhnol. 1977;  1 76-8
  • 13 Jeppsson N. The effects of fertilizer rate on vegetative growth, yield and fruit quality, with special respect to pigments, in black chokeberry (Aronia melanocarpa) cv. ”Viking”.  Sci Hortic. 2000;  83 127-37
  • 14 Skupien K, Oszmianski J. The effect of mineral fertilization on nutritive value and biological activity of chokeberry fruit.  Agric Food Sci. 2007;  16 46-55
  • 15 Martynov E G. Influence of trace elements on the accumulation of anthocyanins in the fruit of Aronia melanocarpa. .  Chem Nat Comp. 1979;  14 451-2
  • 16 Du Q, Jerz G, Winterhalter P. Isolation of two anthocyanin sambubiosides from bilberry (Vaccinium myrtillus) by high-speed counter-current chromatography.  J Chromatogr A. 2004;  1045 59-63
  • 17 Degenhardt A, Knapp H, Winterhalter P. Separation and purification of anthocyanins by high-speed countercurrent chromatography and screening for antioxidant activity.  J Agric Food Chem. 2000;  48 338-43
  • 18 Gilewicz-Lukasik B, Koter S, Kurzawa J. Concentration of anthocyanins by the membrane filtration.  Sep Purif Technol. 2007;  57 418-24
  • 19 Balcerek M, Szopa J S. Optimization of the technology of Aronia spirit production – Part 1: Selection of the fermentation conditions.  Dtsch Lebensmitt Rundsch. 2002;  98 326-31
  • 20 Balcerek M, Szopa J S. Optimization of the technology of Aronia spirit production – Part 2. Influence of the fermentation conditions on the aroma compounds.  Dtsch Lebensmitt Rundsch. 2005;  101 16-9
  • 21 Valcheva-Kuzmanova S V, Belcheva A. Current knowledge of Aronia melanocarpa as a medicinal plant.  Folia Med (Plovdiv). 2006;  48 11-7
  • 22 Krenn L, Steitz M, Schlicht C, Kurth H, Gaedcke F. Anthocyanin- and proanthocyanidin-rich extracts of berries in food supplements – analysis with problems.  Pharmazie. 2007;  62 803-12
  • 23 Wawer I. The power of nature: Aronia melanocarpa, 1st edition. London; Nature's Print Ltd 2006: 1-168
  • 24 Tanaka T, Tanaka A. Chemical components and characteristics of black chokeberry.  J Jpn Soc Food Sci Technol. 2001;  48 606-10
  • 25 Wawer I, Wolniak M, Paradowska K. Solid state NMR study of dietary fiber powders from Aronia, bilberry, black currant and apple.  Solid State Nucl Magn Reson. 2006;  30 106-13
  • 26 Nawirska A, Kwasniewska M. Dietary fibre fractions from fruit and vegetable processing waste.  Food Chem. 2005;  91 221-5
  • 27 Borycka B, Stachowiak J. Relations between cadmium and magnesium and Aronia fractional dietary fibre.  Food Chem. 2008;  107 44-8
  • 28 Wiese S, Kruse H P, Kulling S E. Research project ”Dietary procyanidins – From a better understanding of human health effects to functionalised foods. Bioavailability and biological activity of procyanidins. Internal Report 2008
  • 29 Hofsommer H J, Koswig S. Zum Nachweis von Aronia in schwarzer Johannisbeere.  Flüssiges Obst. 2005;  72 289-93
  • 30 Zlatanov M D. Lipid composition of Bulgarian chokeberry, black currant and rose hip seed oils.  J Sci Food Agric. 1999;  79 1620-4
  • 31 Pliszka B, Huszcza-Ciolkowska G, Wierzbicka E. Effects of extraction conditions on the content of anthocyanins and bioelements in berry fruit extracts.  Commun Soil Sci Plant. 2008;  39 753-62
  • 32 Ognik K, Rusinek E, Sembratowicz I, Truchlinski J. Contents of heavy metals, nitrate (V), and nitrate (III) in fruits of elderberry and black chokeberry depending on harvest site and vegetation period.  Rocz Panstw Zakl Hig. 2006;  57 235-41
  • 33 Stralsjo L, Ahlin H, Witthoft C M, Jastrebova J. Folate determination in Swedish berries by radioprotein-binding assay (RPBA) and high performance liquid chromatography (HPLC).  Eur Food Res Technol. 2003;  216 264-9
  • 34 Razungles A, Oszmianski J, Sapis J C. Determination of carotenoids in fruits of Rosa sp. (Rosa canina and Rosa rugosa) and of chokeberry (Aronia melanocarpa).  J Food Sci. 1989;  54 774-5
  • 35 Milazzo S, Ernst E, Lejeune S, Schmidt K. Laetrile treatment for cancer. Cochrane Database Syst Rev 2006: CD005476
  • 36 Milazzo S, Lejeune S, Ernst E. Laetrile for cancer: a systematic review of the clinical evidence.  Support Care Cancer. 2007;  15 583-95
  • 37 Weinges K, Schick H, Schilling G, Irngartinger H, Oeser T. Composition of an anthocyan concentrate from Aronia melanocarpa Elliot – X-ray analysis of tetraacetyl parasorboside.  Eur J Org Chem. 1998;  1 189-92
  • 38 Hirvi T, Honkanen E. Analysis of the volatile constituents of black chokeberry (Aronia melanocarpa Ell).  J Sci Food Agric. 1985;  36 808-10
  • 39 Kähkönen M P, Hopia A I, Heinonen M. Berry phenolics and their antioxidant activity.  J Agric Food Chem. 2001;  49 4076-82
  • 40 Kraemer-Schafhalter A, Fuchs H, Pfannhauser W. Solid-phase extraction (SPE) – a comparison of 16 materials for the purification of anthocyanins from Aronia melanocarpa var Nero.  J Sci Food Agric. 1998;  78 435-40
  • 41 Kolesnikov M P, Gins V K. Phenolic substances in medicinal plants. Appl Biochem Microbiol 2001; 37 : 392 – 9. Translated from Kolesnikov MP, Gins VK. Phenolic compounds in medicinal plants.  Prikl Biokhim Mikrobiol. 2001;  37 457-65
  • 42 Hudec J, Bakos D, Mravec D, Kobida L, Burdova M, Turianica I. et al . Content of phenolic compounds and free polyamines in black chokeberry (Aronia melanocarpa) after application of polyamine biosynthesis regulators.  J Agric Food Chem. 2006;  54 3625-8
  • 43 Kähkönen M P, Hopia A I, Vuorela H J, Rauha J P, Pihlaja K, Kujala T S. et al . Antioxidant activity of plant extracts containing phenolic compounds.  J Agric Food Chem. 1999;  47 3954-62
  • 44 Mayer-Miebach E, Adamiuk M, Behsnilian D. Research project Dietary procyanidins – From a better understanding of human health effects to functionalised foods. Process engineering to improve procyanidin stability and extractability. Internal Report 2008
  • 45 Oszmianski J, Wojdylo A. Aronia melanocarpa phenolics and their antioxidant activity.  Eur Food Res Technol. 2005;  221 809-13
  • 46 Esatbeyoglu T, Winterhalter P. Research project Dietary procyanidins – From a better understanding of human health effects to functionalised foods. Isolation, characterisation and analysis of procyanidins. Internal Report 2008
  • 47 Wu X L, Gu L W, Prior R L, McKay S. Characterization of anthocyanins and proanthocyanidins in some cultivars of Ribes, Aronia, and Sambucus and their antioxidant capacity.  J Agric Food Chem. 2004;  52 7846-56
  • 48 Jakobek L, Seruga M, Medvidovic-Kosanovic M, Novak I. Anthocyanin content and antioxidant activity of various red fruit juices.  Dtsch Lebensmitt Rundsch. 2007;  103 58-64
  • 49 Benvenuti S, Pellati F, Melegari M, Bertelli D. Polyphenols, anthocyanins, ascorbic acid, and radical scavenging activity of Rubus, Ribes, and Aronia.  J Food Sci. 2004;  69 FCT164-FCT9
  • 50 Strigl A W, Leitner E, Pfannhauser W. Qualitative und quantitative Analyse der Anthocyane in Schwarzen Apfelbeeren (Aronia melanocarpa Michx Ell) mittels TLC, HPLC and UV/VIS-Spectrometrie.  Z Lebensm Unters Forsch. 1995;  201 266-8
  • 51 Minkiewicz P, Pliszka B, Dziuba J, Oszmianski J. Second and third derivatives of UV spectra as a tool for identification of major anthocyanins from Aronia melanocarpa extract, separated using reversed-phase high-performance liquid chromatography.  Collect Czech Chem Commun. 2004;  69 1443-52
  • 52 Bridle P, Timberlake C F. Anthocyanins as natural food colours – selected aspects.  Food Chem. 1997;  58 103-9
  • 53 Malien-Aubert C, Dangles O, Amiot M J. Color stability of commercial anthocyanin-based extracts in relation to the phenolic composition. Protective effects by intra- and intermolecular copigmentation.  J Agric Food Chem. 2001;  49 170-6
  • 54 Wilska Jeszka J, Korzuchowska A. Anthocyanins and chlorogenic acid copigmentation – Influence on the colour of strawberry and chokeberry juices.  Z Lebensm Unters Forsch. 1996;  203 38-42
  • 55 Mattila P, Hellstrom J, Torronen R. Phenolic acids in berries, fruits, and beverages.  J Agric Food Chem. 2006;  54 7193-9
  • 56 Slimestad R, Torskangerpoll K, Nateland H S, Johannessen T, Giske N H. Flavonols from black chokeberries, Aronia melanocarpa. .  J Food Compost Anal. 2005;  18 61-8
  • 57 Manach C, Williamson G, Morand C, Scalbert A, Remesy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies.  Am J Clin Nutr. 2005;  81 230S-42S
  • 58 Prior R L, Gu L. Occurrence and biological significance of proanthocyanidins in the American diet.  Phytochemistry. 2005;  66 2264-80
  • 59 Aron P M, Kennedy J A. Flavan-3-ols: Nature, occurrence and biological activity.  Mol Nutr Food Res. 2008;  52 70-104
  • 60 Rawel H M, Kulling S E. Nutritional contribution of coffee, cacao and tea phenolics to human health.  J Verbr Lebensm. 2007;  2 399-406
  • 61 Zafra-Stone S, Yasmin T, Bagchi M, Chatterjee A, Vinson J A, Bagchi D. Berry anthocyanins as novel antioxidants in human health and disease prevention.  Mol Nutr Food Res. 2007;  51 675-83
  • 62 Duthie S J. Berry phytochemicals, genomic stability and cancer: evidence for chemoprotection at several stages in the carcinogenic process.  Mol Nutr Food Res. 2007;  51 665-74
  • 63 Zheng W, Wang S Y. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries.  J Agric Food Chem. 2003;  51 502-9
  • 64 Valcheva-Kuzmanova S, Gadjeva V, Ivanova D, Belcheva A. Antioxidant activity of Aronia melanocarpa fruit juice in vitro. .  Acta Aliment. 2007;  36 425-8
  • 65 Jakobek L, Seruga M, Novak I, Medvidovic-Kosanovic M. Flavonols, phenolic acids and antioxidant activity of some red fruits.  Dtsch Lebensmitt Rundsch. 2007;  103 369-78
  • 66 Bermudez-Soto M J, Tomas-Barberan F A. Evaluation of commercial red fruit juice concentrates as ingredients for antioxidant functional juices.  Eur Food Res Technol. 2004;  219 133-41
  • 67 Pool-Zobel B L, Bub A, Schroder N, Rechkemmer G. Anthocyanins are potent antioxidants in model systems but do not reduce endogenous oxidative DNA damage in human colon cells.  Eur J Nutr. 1999;  38 227-34
  • 68 Moyer M P, Hummer K E, Finn C E, Frei B, Wrolstad R E. Anthocyanins, phenolics, and antioxidant capacity in diverse small fruits: Vaccinium, Rubus, and Ribes. .  J Agric Food Chem. 2002;  50 519-25
  • 69 Kalt W, Forney C F, Martin A, Prior R L. Antioxidant capacity, vitamin C, phenolics, and anthocyanins after fresh storage of small fruits.  J Agric Food Chem. 1999;  47 4638-44
  • 70 Ehlenfeldt M K, Prior R L. Oxygen radical absorbance capacity (ORAC) and phenolic and anthocyanin concentrations in fruit and leaf tissues of highbush blueberry.  J Agric Food Chem. 2001;  49 2222-7
  • 71 Wang S Y, Stretch A W. Antioxidant capacity in cranberry is influenced by cultivar and storage temperature.  J Agric Food Chem. 2001;  49 969-74
  • 72 Wang H, Cao G, Prior R L. Total antioxidant capacity of fruits.  J Agric Food Chem. 1996;  44 701-5
  • 73 Seeram N P, Aviram M, Zhang Y, Henning S M, Feng L, Dreher M. et al . Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States.  J Agric Food Chem. 2008;  56 1415-22
  • 74 Gil M I, Tomas-Barberan F A, Hess-Pierce B, Holcroft D M, Kader A A. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing.  J Agric Food Chem. 2000;  48 4581-9
  • 75 Hider R C, Liu Z D, Khodr H H. Metal chelating of polyphenols. In: Packer L, editor Methods in enzymology, flavonoids and other polyphenols, Vol. 335. San Diego; Academic Press 2001: 190-203
  • 76 Scalbert A, Deprez S, Mila I, Albrecht A M. Proanthocyanidins and human health: Systemic effects and local effects in the gut.  Biofactors. 2000;  13 115-20
  • 77 Faff J, Frankiewicz-Jozko A. Effect of anthocyanins from Aronia melanocarpa on the exercise-induced oxidative stress in rat tissues.  Biol Sport. 2003;  20 15-23
  • 78 Frankiewicz-Jozko A, Faff J. Effect of anthocyanin pigments from fruits of Aronia melanocarpa on the exercise-induced increase in lipid peroxidation marker in rat tissues.  Biol Sport. 1999;  16 31-8
  • 79 Kowalczyk E, Charyk K, Fijalkowski P, Niedworok J, Blaszczyk J, Kowalski J. Protective influence of natural anthocyanins of Aronia melanocarpa on selected parameters of antioxidative status in experimental intoxication with sulphide-2-chloroethyl-3-chloropropyl.  Pol J Environ Stud. 2004;  13 339-41
  • 80 Kowalczyk E, Kopff A, Niedworok J, Kopff M, Jankowski A. Anthocyanins – an adjunct to cardiovascular therapy?.  Kardiol Pol. 2002;  57 332-6
  • 81 Matsumoto M, Hara H, Chiji H, Kasai T. Gastroprotective effect of red pigments in black chokeberry fruit (Aronia melanocarpa Elliot) on acute gastric hemorrhagic lesions in rats.  J Agric Food Chem. 2004;  52 2226-9
  • 82 Pilaczynska-Szczesniak L, Skarpanska-Steinborn A, Deskur E, Basta P, Horoszkiewicz-Hassan M. The influence of chokeberry juice supplementation on the reduction of oxidative stress resulting from an incremental rowing ergometer exercise.  Int J Sport Nutr Exerc Metab. 2005;  15 48-58
  • 83 Malik M, Zhao C W, Schoene N, Guisti M M, Moyer M P, Magnuson B A. Anthocyanin-rich extract from Aronia meloncarpa E. induces a cell cycle block in colon cancer but not normal colonic cells.  Nutr Cancer. 2003;  46 186-96
  • 84 Zhao C, Giusti M M, Malik M, Moyer M P, Magnuson B A. Effects of commercial anthocyanin-rich extracts on colonic cancer and nontumorigenic colonic cell growth.  J Agric Food Chem. 2004;  52 6122-8
  • 85 Bermudez-Soto M J, Larrosa M, Garcia-Cantalejo J M, Espin J C, Tomas-Barberan F A, Garcia-Conesa M. Up-regulation of tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 in human colon cancer Caco-2 cells following repetitive exposure to dietary levels of a polyphenol-rich chokeberry juice.  J Nutr Biochem. 2007;  18 259-71
  • 86 Lala G, Malik M, Zhao C W, He J, Kwon Y, Giusti M M. et al . Anthocyanin-rich extracts inhibit multiple biomarkers of colon cancer in rats.  Nutr Cancer. 2006;  54 84-93
  • 87 Cooke D, Schwarz M, Boocock D, Winterhalter P, Steward W P, Gescher A J. et al . Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis – relationship with tissue anthocyanin levels.  Int J Cancer. 2006;  119 2213-20
  • 88 Ding M, Feng R, Wang S Y, Bowman L, Lu Y, Qian Y. et al . Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity.  J Biol Chem. 2006;  281 17 359-68
  • 89 Gasiorowski K, Szyba K, Brokos B, Kolaczynska B, Jankowiak Wlodarczyk M, Oszmianski J. Antimutagenic activity of anthocyanins isolated from Aronia melanocarpa fruits.  Cancer Lett. 1997;  119 37-46
  • 90 Atanasova-Goranova V K, Dimova P I, Pevicharova G T. Effect of food products on endogenous generation of N-nitrosamines in rats.  Br J Nutr. 1997;  78 335-45
  • 91 Kowalczyk E, Kopff A, Fijalkowski P, Kopff M, Niedworok J, Blaszczyk J. et al . Effect of anthocyanins on selected biochemical parameters in rats exposed to cadmium.  Acta Biochim Pol. 2003;  50 543-8
  • 92 Valcheva-Kuzmanova S, Borisova P, Galunska B, Krasnaliev I, Belcheva A. Hepatoprotective effect of the natural fruit juice from Aronia melanocarpa on carbon tetrachloride-induced acute liver damage in rats.  Exp Toxicol Pathol. 2004;  56 195-201
  • 93 Zapolska-Downar D, Kosmider A, Naruszewicz M. Flavonoids-rich extract from chokeberry fruits inhibits oxLDL-induced apoptosis of endothelial cells.  Atherosclerosis Suppl. 2006;  7 223
  • 94 Han G L, Li C M, Mazza G, Yang X G. Effect of anthocyanin rich fruit extract on PGE2 produced by endothelial cells.  Wei Sheng Yan Jiu. 2005;  34 581-4
  • 95 Olas B, Wachowicz B, Tomczak A, Erler J, Stochmal A, Oleszek W. Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro. .  Platelets. 2008;  19 70-7
  • 96 Ryszawa N, Kawczynska-Drozdz A, Pryjma J, Czesnikiewicz-Guzik M, Adamek-Guzik T, Naruszewicz M. et al . Effects of novel plant antioxidants on platelet superoxide production and aggregation in atherosclerosis.  J Physiol Pharmacol. 2006;  57 611-26
  • 97 Bell D R, Burt T D. Phenolic acids contained in anthocyanin enriched extracts from elderberry, bilberry and chokeberry possess endothelium dependent and independent vasorelaxation properties in porcine coronary arteries.  Faseb J. 2007;  21 A366
  • 98 Bell D R, Gochenaur K. Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts.  J Appl Physiol. 2006;  100 1164-70
  • 99 Valcheva-Kuzmanova S, Kuzmanov K, Mihova V, Krasnaliev I, Borisova P, Belcheva A. Antihyperlipidemic effect of Aronia melanocarpa fruit juice in rats fed a high-cholesterol diet.  Plant Foods Hum Nutr. 2007;  62 19-24
  • 100 Valcheva-Kuzmanova S, Kuzmanov K, Tancheva S, Belcheva A. Hypoglycemic and hypolipidemic effects of Aronia melanocarpa fruit juice in streptozotocin-induced diabetic rats.  Methods Find Exp Clin Pharmacol. 2007;  29 101-5
  • 101 Valcheva-Kuzmanova S, Kuzmanov K, Tsanova-Savova S, Mihova V, Krasnaliev I, Borisova P. et al . Lipid-lowering effects of Aronia melanocarpa fruit juice in rats fed cholesterol-containing diets.  J Food Biochem. 2007;  31 589-602
  • 102 Skoczynska A, Jedrychowska I, Poreba R, Affelska-Jercha A, Turczyn B, Wojakowska A. et al . Influence of chokeberry juice on arterial blood pressure and lipid parameters in men with mild hypercholesterolemia.  Pharmacol Rep. 2007;  59 177-82
  • 103 Skoczynska A, Jedrychowska I, Poreba R, Affelska A, Turczyn B. The influence of chokeberry juice on arterial blood pressure.  Pharmacol Rep. 2007;  59 (Suppl. 1) 66
  • 104 Naruszewicz M, Laniewska I, Millo B, Dluzniewski M. Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infarction (MI).  Atherosclerosis. 2007;  194 e179-84
  • 105 Naruszewicz M, Daniewski M, Laniewska I, Pikto-Pietkiewicz W, Millo B, Zapolska-Downar D. Effect of anthocyanins from chokeberry (Aronia melanocarpa) on blood pressure, inflammatory mediators and cell adhesion molecules in patients with a history of myocardial infarction (MI).  Atherosclerosis Suppl. 2003;  4 143
  • 106 Simeonov S B, Botushanov N P, Karahanian E B, Pavlova M B, Husianitis H K, Troev D M. Effects of Aronia melanocarpa juice as part of the dietary regimen in patients with diabetes mellitus.  Folia Med (Plovdiv). 2002;  44 20-3
  • 107 Naruszewicz M, Laniewska I, Millo B, Dluzniewski M. Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infraction (MI).  Atherosclerosis. 2007;  194 e179-84
  • 108 Peng X, Cheng K W, Ma J, Chen B, Ho C T, Lo C. et al . Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts.  J Agric Food Chem. 2008;  56 1907-11
  • 109 Urios P, Grigorova-Borsos A M, Peyroux J, Sternberg M. Inhibition of advanced glycation by flavonoids. A nutritional implication for preventing diabetes complications.  J Soc Biol. 2007;  201 189-98
  • 110 Pinent M, Blay M, Blade M C, Salvado M J, Arola L, Ardevol A. Grape seed-derived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines.  Endocrinology. 2004;  145 4985-90
  • 111 Zielinska-Przyjemska M, Olejnik A, Dobrowolska-Zachwieja A, Grajek W. Effects of Aronia melancarpa polyphenols on oxidative metabolism and apoptosis of neutrophils from obese and non-obese individuals.  Acta Sci Pol Technol Aliment. 2007;  6 75-87

Prof. Dr. Sabine E. Kulling

University of Potsdam

Institute of Nutritional Science

Department of Food Chemistry

Arthur-Scheunert-Allee 114 – 116

14558 Nuthetal (OT Bergholz-Rehbrücke)

Germany

Telefon: +49-33200-88-580

Fax: +49-33200-88-582

eMail: kulling@uni-potsdam.de