Cytotoxic ent-Kaurane Diterpenoids from Isodon henryi

Abstract

Chromatographic fractionation of the extract of Isodon henryi resulted in the isolation of seven new ent-kaurane diterpenoids, named minheryins A-G (1 – 7), together with the six known ent-kaurane diterpenoids leukamenin F (8), excisoidesin (9), leukamenin E (10), wangzaozin A (11), pseurata A (12), and racemosin A (13), which were elucidated by spectroscopic analysis. Compounds 7 – 13 were tested for their cytotoxicity against K562 and HepG2 cell lines, and they all exhibited significant activities with IC₅₀ values <0.50 μg/mL. Isolates 1 – 5 were evaluated against the K562 cell line, and only 3 showed weak activity.

Key words

Labiatae - Isodon henryi - ent-kaurane diterpenoid - cytotoxicity

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