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DOI: 10.1055/s-0028-1088342
© Georg Thieme Verlag KG Stuttgart · New York
Effect of Constituents from Fructus Aurantii Immaturus and Radix Paeoniae Alba on Gastrointestinal Movement
Publikationsverlauf
Received: January 19, 2008
Revised: August 10, 2008
Accepted: September 23, 2008
Publikationsdatum:
18. November 2008 (online)
![](https://www.thieme-connect.de/media/plantamedica/200901/lookinside/thumbnails/10.1055-s-0028-1088342-1.jpg)
Abstract
Fructus Aurantii Immaturus and Radix Paeoniae Alba Powder (FPP) is a popular Chinese herbal prescription. The combination of Fructus Aurantii Immaturus and Radix Paeoniae Alba has been used to treat gastrointestinal disorders for hundreds of years. To our interest, this combination shows a bilateral effect on gastrointestinal peristalsis. Our present study was focused on the bilateral role of this combination on the gastrointestinal tract. The effective constituents and mechanisms were explored. Six monomer constituents from Radix Paeoniae Alba and Fructus Aurantii Immaturus were screened by intestinal transit assay. The bilateral roles of three effective constituents were authenticated by gastric emptying assay, and the combination of three constituents showed a bilateral effect. Then, the mediating receptors and the role of NO and NF-κB p65 were examined to determine the mechanism involved. The overall results suggest that the major effective constituents of this combination are synephrine, hesperidin and paeoniflorin. Synephrine inhibits the gastrointestinal movement, while hesperidin stimulates it. Paeoniflorin shows different effects on intestinal and gastric activity. The effect of synephrine relies on the α-adrenergic receptor, and the effect of hesperidin is mediated via the H1 histamine receptor. The regulation of hesperidin and synephrine on NF-κB p65 translocation and NO production through the α-receptor and the H1 receptor, respectively, is involved in the bilateral effect of the Fructus Aurantii Immaturus-Radix Paeoniae Alba combination.
Key words
Citrus aurantium L. - Rutaceae - Paeonia lactiflora Pall - Paeoniaceae - gastrointestinal movement
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Jian-Wen Liu
State Key Laboratory of Bioreactor Engineering and School of Pharmacy
East China University of Science and Technology
130 Meilong Road
Shanghai 200237
People’s Republic of China
Telefon: +86-21-6425-2044
Fax: +86-21-6425-2044
eMail: Liujian@ecust.edu.cn
Guang Ji
Laboratory of Liver Disease
Longhua Hospital
Shanghai University of Traditional Chinese Medicine
725 Wanping South Road
Shanghai 200032
People’s Republic of China
Telefon: +86-21-6428-6261
Fax: +86-21-6428-6261
eMail: jiliver@vip.sina.com