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Planta Med 2009; 75(2): 142-145
DOI: 10.1055/s-0028-1088390
Pharmacology
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Protective Effect of 4-Methoxy-5-hydroxycanthin-6-one, A Natural Alkaloid, on Dextran Sulfate Sodium-Induced Rat Colitis

Jun-Feng Liu1 , 3 , Meng Shao2 , 3 , Da-Wei Zhai3 , Ke Liu4 , Li-Jun Wu1
  • 1School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Liaoning, P. R. China
  • 2College of life Science, Jilin University, Jilin, P. R. China
  • 3Shandong Target-drug Research Co., Ltd., Shandong, P. R. China
  • 4School of Pharmacy, Yantai University, Shandong, P. R. China
Further Information

Publication History

Received: May 12, 2008 Revised: September 29, 2008

Accepted: October 6, 2008

Publication Date:
15 December 2008 (online)

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Abstract

In the present study, we evaluated the effect of 4-methoxy-5-hydroxycanthin-6-one (CAN), a natural alkaloid isolated from Picrasma quassioides (D.Don) Benn., on ulcerative colitis induced by dextran sulfate sodium (DSS) in rats in comparison with the positive control drug, sulfasalazine (SASP). Given orally for several days, CAN significantly reduced the severity of colitis and mitigated changes in colon length, colon mucosa myeloperoxidase (MPO) activity, and the level of tumor necrosis factor-α (TNF-α) in serum. The effect of CAN was similar to that of SASP. These results suggest that CAN treatment might be an effective therapeutic intervention against ulcerative colitis induced by DSS.

Abbreviations

CAN:4-methoxy-5-hydroxycanthin-6-one

DSS:dextran sulfate sodium

IBD:inflammatory bowel disease

MPO:myeloperoxidase

SASP:sulfasalazine

TNF-α:tumor necrosis factor-α

UC:ulcerative colitis

Key words

ulcerative colitis - DSS - Picrasma quassioides (D. Don) Benn. - Simaroubaceae - MPO - TNF-α - 4-methoxy-5-hydroxycanthin-6-one

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Prof. Dr. Li-Jun Wu

School of Traditional Chinese Medicine

Shenyang Pharmaceutical University

Shenyang 110016

People’s Republic of China

Phone: +86-24-2398-6481

Fax: +86-24-2398-6481

Email: wulijun_111@hotmail.com

    www.thieme-connect.de/ejournals/toc/plantamedica