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Dtsch Med Wochenschr 2008; 133(42): 2168-2172
DOI: 10.1055/s-0028-1091258
DOI: 10.1055/s-0028-1091258
Prinzip & Perpektive | Review article
Viszeral- und Transplantationschirurgie
© Georg Thieme Verlag KG Stuttgart · New York
Akuter Sauerstoffmangel und Hypoxietoleranz
Oxygen deprivation and hypoxia toleranceWeitere Informationen
Publikationsverlauf
eingereicht: 15.4.2008
akzeptiert: 23.7.2008
Publikationsdatum:
07. Oktober 2008 (online)

Schlüsselwörter
Hypoxie - Hypoxietoleranz - HIF-Prolyl-Hydroxylase
Key words
hypoxia - hypoxia tolerance - HIF prolyl hydroxylase
Literatur
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- 2 Aragones J, Schneider M, Van Geyte K. et al . Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nature genetics. 2008; 40 170-180
- 3 Beall C M. High-altitude adaptations. Lancet. 2003; 362 Suppl s14-15
- 4 Bernhardt W M, Warnecke C, Willam C. et al . Organ protection by hypoxia and hypoxia-inducible factors. Methods in enzymology. 2007; 435 221-245
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- 7 Epstein A C, Gleadle J M, McNeill L A. et al . C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 2001; 107 43-54
- 8 Fandrey J, Gorr T A, Gassmann M. Regulating cellular oxygen sensing by hydroxylation. Cardiovasc Res. 2006; 71 642-651
- 9 Kim J W, Tchernyshyov I, Semenza G L, Dang C V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006; 3 177-185
- 10 Majno G, Joris I. Apoptosis, oncosis, and necrosis. An overview of cell death. The American journal of pathology. 1995; 146 3-15
- 11 Nangaku M, Eckardt K U. Hypoxia and the HIF system in kidney disease. Journal of molecular medicine (Berlin, Germany). 2007; 85 1325-1330
- 12 Schlaifer J D, Kerensky R A. Ischemic preconditioning: clinical relevance and investigative studies. Clinical cardiology. 1997; 20 602-606
- 13 Schmidt J, Muller S A, Mehrabi A, Schemmer P, Buchler M W. [Orthotopic liver transplantation: Techniques and results.]. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen. 2008; 79 112-120
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Dr. med. Martin Schneider
Emmy Noether-Gruppenleiter, Universitätsklinikum
Heidelberg, Abteilung für Allgemein-, Viszeral-
und Transplantationschirurgie
Im Neuenheimer Feld 110
69120 Heidelberg
Telefon: 06221/56-37876
Fax: 06221/56-5506
eMail: martin.schneider@med.uni-heidelberg.de