1 Preparation of this review and work of the authors was supported by grants RR-51 from the General Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health; HL-02262 from the National Heart Institute, two grants from the Colorado Heart Association, Denver, Colo.; Research Career Development Award AM 19578, Veterans Administration Research Allocation 554-01-2920.01-170,01 and a grant from the Milheim Foundation for Cancer Research, Denver, Colo.