Prophylactic Effect of L-5-Hydroxytryptophan on Self-Mutilation in the Lesch-Nyhan Syndrome

Teiichi Mizuno; Yasumi Yugari

doi:10.1055/s-0028-1091647

Neuropädiatrie, Inhaltsverzeichnis

Neuropediatrics 1975; 6(1): 13-23
DOI: 10.1055/s-0028-1091647

Original article

Prophylactic Effect of L-5-Hydroxytryptophan on Self-Mutilation in the Lesch-Nyhan Syndrome

Teiichi Mizuno, Yasumi Yugari

The Health Service Center, Ochanomizu University, Tokyo, and The Research Institute for Life Sciences, Central Research Laboratories, Ajinomoto Co., Inc., Yokohama

Abstract

Four cases of the Lesch-Nyhan syndrome found in the Tokyo area were given L-5-hydroxytryptophan orally. L-5-hydroxytryptophan relieved self-mutilation effectively without causing any side effects. However this substance did not alleviate choreoathetoid movement. Self-destructive behavior may be caused by an imbalance of cerebral amines, especially of serotonin.

L-5-hydroxytryptophan - Lesch-Nyhan syndrome - Self-mutilation

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