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Horm Metab Res 1979; 11(2): 90-94
DOI: 10.1055/s-0028-1092686
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© Georg Thieme Verlag KG Stuttgart · New York

The Acute Effects of 5HTP, Fluoxetine and Quipazine on Insulin and Glucagon Release in the Intact Rat

J. H. Jacoby , G. F. Bryce
  • Department of Pharmacology, New Jersey Medical School, College of Medicine and
    Dentistry of New Jersey, Newark, New Jersey and
    Department of Cell Biology, Roche Research Center, Nutley, New Jersey, U.S.A.
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Publication History

Publication Date:
17 December 2008 (online)

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Abstract

5-hydroxytryptophan (5HTP), the immediate precursor of serotonin, induces a release of insulin and glucagon in the intact rat. These effects of 5HTP, which have previously been shown to be blocked by L-aromatic amino acid decarboxylase inhibition, were also prevented by methysergide (a serotonin receptor antagonist). Quipazine (a serotonin receptor agonist) did not alter pancreatic hormone release. Fluoxetine, a serotonin neuronal reuptake blocker did not effect insulin secretion and had a slight glucagon stimulatory effect, however the effects of 5HTP on insulin and glucagon release were not potentiated by fluoxetine pretreatment. Alpha and beta-adrenergic receptor blockade did not alter the pancreatic effects of 5HTP.

Key words

Insulin Release - Glucagon Release - 5HTP - Fluoxetine - Adrenergic Receptor Blockade - Methysergide - Quipazine