Kinetic Analysis of Plasma TSH Dynamics after TRH Stimulation

Abstract

Kinetic analysis of the time course of plasma TSH after TRH stimulation was performed by means of a single compartment model with first order input. This kinetic model showed satisfactory fit to the data, and was found to be useful enough for the characterization of plasma TSH dynamics. In endocrinologically normal short children, the amount of TSH release per unit volume of distribution space (Q₀/V), the rate constant for the TSH release (α), and the rate constant for TSH elimination (β) were averaged 23.4 µU/ml, 6.981 hr^-1 and 0.813 hr^-1, respectively. Elevated Q₀/V values with lowered α and β were obtained in the hypothyroid children. Variable results, with the exception of low a values, were obtained in the children with pituitary dwarfism.

Key words

TRH - TSH - First Order Kinetic Model