Response of Plasma Somatostatin-Like Immunoreactivity to the Administration of Alloxan in Dogs

V. Schusdziarra; Virginia Harris; R. Unger

doi:10.1055/s-0028-1092760

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1979; 11(8): 457-459
DOI: 10.1055/s-0028-1092760

Originals

Response of Plasma Somatostatin-Like Immunoreactivity to the Administration of Alloxan in Dogs

V. Schusdziarra , Virginia Harris , R. Unger [*]

Dallas Veterans Administration Hospital, the Department of Internal Medicine of the University of Texas Southwestern Medical School, Dallas, Texas

Abstract

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Abstract

The present study was designed to examine the effects of intravenously injected alloxan (75 mg/kg) upon plasma somatostatin-like immunoreactivity (SLI), glucagon (IRG), insulin (IRI) and glucose levels in 6 dogs. Within 2 hours of the injection of alloxan, SLI and IRI levels decreased significantly below their respective baselines, while IRG and plasma glucose concentrations increased. At 8 hours SLI levels had increased significantly by 55 pg/ml, together with a rise in IRI and a decrease in IRG and glucose concentrations. After 24 hours, marked hyperglycemia and hyperglucagonemia had developed whereas SLI levels were not different from preinjection values.

Key words

Plasma Somatostatin - Like Immunoreactivity - Alloxan - Dogs

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References

1 Dr. Unger is Senior Medical Investigator of the Veterans Administration