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Horm Metab Res 1979; 11(10): 547-549
DOI: 10.1055/s-0028-1092777
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© Georg Thieme Verlag KG Stuttgart · New York

Glucose, Insulin and Somatostatin Infusion for the Determination of Insulin Resistance in Liver Cirrhosis

A. V. Greco , A. G. Rebuzzi , L.  Altomonte , R.  Manna , A.  Bertoli , G.  Ghirlanda
  • Istituto di Patologia Medica, Catholic University, Rome, Italy
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Publication History

Publication Date:
17 December 2008 (online)

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Abstract

Twelve patients with liver cirrhosis and ten normal subjects were studied. Using a constant intravenous infusion of glucose, insulin and somatostatin over 2 1/2 hours we determined the steady state plasma glucose level (SSPG) in order to measure insulin resistance.

The results demonstrated that the cirrhotic patients were insulin resistant compared to normals and that plasma glucagon does not account for the insulin resistance in these patients.

Key words

Insulin Resistance - Liver Cirrhosis - Somatostatin - Glucose - Insulin - Glucagon