Abstract
Metabolic alkalosis was induced in starved mice by treatment with NaHCO3, which did not significantly alter the blood glucose concentration, but protected against the diabetogenic effect of subsequently given alloxan. This protection and the alkalosis had disappeared 4 hr after NaHCO3 treatment. Protection against alloxan, and metabolic alkalosis, were found also in starved mice pre treated with sodium lactate. The findings indicate that metabolic alkalosis, directly or indirectly, protects against alloxan toxicity in vivo.
Key words
Mice - Pancreatic Islets - Alloxan Diabetes - Alkalosis - Sodium Lactate - Electron Microscopy
1 Supported by grants from the Swedish Medical Research Council (Project No. B77-12X-00718-12C).
