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Horm Metab Res 1978; 10(6): 477-481
DOI: 10.1055/s-0028-1093375
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© Georg Thieme Verlag KG Stuttgart · New York

Effect of Metabolic Alkalosis on the B-Cell Sensitivity to Alloxan In Vivo[*]

L.  Boquist
  • Department of Pathology, University of Umeå, Umeå, Sweden
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

Metabolic alkalosis was induced in starved mice by treatment with NaHCO3, which did not significantly alter the blood glucose concentration, but protected against the diabetogenic effect of subsequently given alloxan. This protection and the alkalosis had disappeared 4 hr after NaHCO3 treatment. Protection against alloxan, and metabolic alkalosis, were found also in starved mice pre treated with sodium lactate. The findings indicate that metabolic alkalosis, directly or indirectly, protects against alloxan toxicity in vivo.

Key words

Mice - Pancreatic Islets - Alloxan Diabetes - Alkalosis - Sodium Lactate - Electron Microscopy

1 Supported by grants from the Swedish Medical Research Council (Project No. B77-12X-00718-12C).

1 Supported by grants from the Swedish Medical Research Council (Project No. B77-12X-00718-12C).