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Horm Metab Res 1978; 10(5): 425-428
DOI: 10.1055/s-0028-1093406
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© Georg Thieme Verlag KG Stuttgart · New York

Prenatal Development of Acid β-Glycosidases in the Rat Liver, Effect of Triiodothyronine or Cortisone Administered to Pregnant Rats

Carolyn  Horowitz , H. C. Lau , Jocelyn  Jumawan , O.  Koldovsky
  • Division of Biochemical Development and Molecular Diseases, Children's Hospital of Philadelphia, and the Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, U.S.A.
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

We have found that acid β-galactosidase, β-glucuronidase and N-acetyl-β-glucosaminidase in the rat fetal liver increase during the last week of pregnancy. These enzyme activities were influenced by treatment of pregnant rats (daily from day 16) with L-tri-iodothyronine (20 or 50 µg/100 gm b.w.) or cortisone acetate (10 or 50 mg/100 gm b.w.) as studied in their fetuses obtained on day 22 by caesarian section.

Key words

Rat Fetus - Acid β-Glycosidases - L-Tri-Iodothyronine - Cortisone