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Horm Metab Res 1978; 10(5): 434-438
DOI: 10.1055/s-0028-1093408
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© Georg Thieme Verlag KG Stuttgart · New York

Actions of Salbutamol in Late Pregnancy

Serum Levels of Human Chorionic Gonadotropin, Human Placental Lactogen, Total Oestriol and Progesterone in Diabetic and Non-Diabetic Women during Infusion of SalbutamolK.  Carlström , N. O. Lunell , B.  Persson , J.  Wager
  • Hormone Laboratory, Department of Obstetrics and Gynecology, Sabbatsbergs Hospital, Department of Obstetrics and Gynecology, Huddinge Hospital and Department of Pediatrics, St. Görans Hospital, Karolinska Institute, Stockholm, Sweden
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Publication Date:
23 December 2008 (online)

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Abstract

The acute effects of salbutamol on the serum levels of hPL, hCG, oestriol and progesterone in diabetic and non-diabetic pregnant women in the last trimester were studied. I.V. administration of salbutamol in an increasing dose from 0 to 22.5 ug/min caused no change in hPL or hCG levels in any group. Progesterone showed a significant fall after 40 min in the diabetic group and a less pronounced, although still significant fall after 80 min in the non-diabetic group. The oestriol levels increased significantly after 40 min in the diabetic group while no significant change was noted in the non-diabetic group. It is speculated that the effects in the diabetic women might be explained by a redistribution of the available placental 5-pregnenolone due to an increased fetal conversion into oestriol. This might be due to an increased sensitivity of the adrenal cortex of these foetuses to a supposed stimulatory effect of salbutamol.

Key words

Pregnancy - Diabetes - Human Chorionic Gonadotrophin - Human Placental Lactogen - Oestriol - Progesterone