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Horm Metab Res 1978; 10(4): 263-268
DOI: 10.1055/s-0028-1093411
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© Georg Thieme Verlag KG Stuttgart · New York

Muscle Metabolism during Exercise in Diabetics and in Obese during Starvation

P.  Dieterle , I.  Bachl , G.  Bachl , J.  Henner , D.  Frommeld , P.  Minkus , C.  Dieterle , K. P. Hesse , F.  Nassehinajad
  • 3. Med. Abteilung, Städtisches Krankenhaus München-Neuperlach, Germany
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Publication Date:
23 December 2008 (online)

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Abstract

The influence of exercise on forearm muscle metabolism was examined in 9 healthy subjects, in 16 diabetics and in 4 obese subjects during complete starvation.

During exercise glucose uptake rose 7-8 fold in the controls. However, no increase of glucose uptake was observed in the other groups studied. Moreover, a glucose production from the working muscle took place in about 40 percent of both the diabetic patients and the starved obese subjects. The non-utilization of glucose during physical work in the diabetic like states was accompanied by a significantly diminished lactate output. The arterial concentration of FFA, glycerol, β-HOB and Acac was markedly elevated in the starved obese patients. The FFA-uptake at rest and during exercise, however, was not different from results of controls. Whereas an efflux of β-HOB has been observed during exercise, Acac uptake was increased in these patients.

It is suggested that in maturity onset and starvation diabetes glycolysis is inhibited.

Key words

Muscle Metabolism - Diabetes - Starvation - Glucose Production from Working Muscle - Inhibition of Glycolysis