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Horm Metab Res 1978; 10(4): 280-282
DOI: 10.1055/s-0028-1093414
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© Georg Thieme Verlag KG Stuttgart · New York

Effect of Alrestatin on Arginine-Induced Secretion of Glucagon and Insulin in the Rat

W.  Lippmann , M.  Kobric
  • Biochemical Pharmacology Department, Ayerst Research Laboratories, Montreal, Quebec. Canada
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Publikationsdatum:
23. Dezember 2008 (online)

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Abstract

Alrestatin, a lens aldose reductase inhibitor, decreased i.v. arginine-induced glucagon levels and augmented arginine-stimulated insulin release in the ether anesthetized rat. Alrestatin may then be useful in the treatment of diabetes mellitus, due to its actions on insulin and glucagon, and its capacity to delay the onset of sugar-induced cataracts in the rat.

Key words

Alrestatin - Lens Aldose Reductase - Inhibition of Arginine-induced Glucagon Release - Augmentation of Arginine-Induced Insulin Release - Diabetes