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Horm Metab Res 1978; 10(4): 283-286
DOI: 10.1055/s-0028-1093415
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© Georg Thieme Verlag KG Stuttgart · New York

The Effects of Xenopsin on Endocrine Pancreas and Gastric Antrum in Dogs

K.  Kawanishi , A.  Goto , T.  Ishida , K.  Kawamura , Y.  Nishina , S.  Machida , S.  Yamamoto , T.  Ofuji
  • Third Department of Internal Medicine, Okayama University Medical School, Okayama, Japan
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

Effects of synthetic xenopsin on endocrine pancreas and gastric antrum in anesthetized dogs were studied. Synthetic xenopsin was administered into the superior pancreaticoduodenal artery and plasma insulin, glucagon and gastrin in the superior pancreaticoduodenal vein and gastrin in the right gastroepiploic vein were measured radioimmunologically. Administration of 10 µg of xenopsin per kg of body weight brought about a hyperglycemic response and rapid and sharp elevations of the hormones in the pancreatic vein. Plasma gastrin level in the gastric vein also showed an immediate and sharp increase following xenopsin administration. Xenopsin appeared more potent inducer, of the glucagon. It is concluded that xenopsin acts directly on endocrine pancreas and gastric antrum to secrete their hormones.

Key words

Xenopsin - Insulin - Glucagon - Gastrin