Thyroid Function in Acute Intermittent Porphyria: A Neurogenic Cause of Hyperthyroidism?

M. J. Brodie; D. J. M. Graham; A. Goldberg; G. H. Beastall; W. A. Ratcliffe; J. G. Ratcliffe; P. P. B. Yeo

doi:10.1055/s-0028-1093424

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Horm Metab Res 1978; 10(4): 327-331
DOI: 10.1055/s-0028-1093424

Originals

Thyroid Function in Acute Intermittent Porphyria: A Neurogenic Cause of Hyperthyroidism?

M. J. Brodie¹ , D.J. M. Graham¹ , A. Goldberg¹ , G. H. Beastall² , W. A. Ratcliffe² , J. G. Ratcliffe² , P.P. B. Yeo³

¹University of Glasgow, Department of Materia Medica, Stobhill General Hospital, Glasgow, G21 3UW, United Kingdom
²Radioimmunoassay Unit, Department of Clinical Chemistry, Royal Infirmary, Glasgow, G4 OSF, United Kingdom
³Department of Medicine (Endocrine Unit), Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4 LP, United Kingdom

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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

Thyroid function was investigated in 17 patients with acute intermittent porphyria (AIP). In 13 patients in remission and latent for the disease, thyroid function was normal. In contrast, transient hyperthyoridism with elevated total T₄, T₃, free T₄ and T₃, and FTI levels occurred in one pregnant patient with severe attacks of AIP, and similar, though less pronounced, alterations in thyroid function were found in three other symptomatic female patients. It is suggested that increased thyroidal sympathetic neural stimulation is responsible for these changes in thyroid function.

Key words

Hyperthyroidism - Porphyria - Thyroid Hormones